【摘要】 近年来，我国结直肠腺瘤(colorectal adenoma，CRA)的发生率及结直肠癌(colorectal cancer，CRC)的发生率、病死率明显升高。间歇性禁食(intermittent fasting，IF)作为一种饮食干预方式，在延缓衰老、调节脂质代谢、改善胰岛素敏感性、减轻氧化应激、调节肠道菌群等方面具有突出优势。而目前在我国，对于IF防治CRA的关注度不足，这可能与IF这种饮食干预方式不被人们熟知有关。IF对于CRA危险因素的发生、疾病的发展等方面具有重要影响，本文将对近年来IF对CRA危险因素的影响及其机制做一综述，旨在为CRA的防治提供新思路。

    【关键词】 结直肠腺瘤 间歇性禁食 危险因素 研究进展

    Research Progress on the Influence of Intermittent Fasting on Colorectal Adenoma Risk Factors/MA Lingtong， XIAO Jun. //Medical Innovation of China， 2025， 22(09)： -179

    [Abstract] In recent years， the incidence of colorectal adenoma (CRA) and the incidence and fatality rate of colorectal cancer (CRC) are significantly increased in China. Intermittent fasting (IF)， as a dietary intervention， has outstanding advantages in delaying aging， regulating lipid metabolism， improving insulin sensitivity， alleviating oxidative stress and regulating intestinal flora. At present， in China， there is insufficient attention to the prevention and treatment of CRA by IF， which may be related to the fact that the dietary intervention mode of IF is not well known. IF has an important impact on the occurrence of CRA risk factors and the development of diseases. This paper will review the impact of IF on CRA risk factors and its mechanism in recent years ......