The Impact of Thoracic Paravertebral Block Combined with General Anesthesia on Cognitive Function in Elderly Patients Undergoing Radical Resection of Lung Cancer/YANG Li， AN Xiaolei， ZHANG Jin. //Medical Innovation of China， 2025， 22(10)： 019-023

    [Abstract]Objective： To investigate the effect of thoracic paravertebral block combined with general anesthesiaoncognitive function inelderly patients undergoing radicalresection of lungcancer.Method：Prospectively enrolled 80elderly patientswhounderwentradicalresectionof lung cancer atXuzhou MunicipalHospital Afiliated to Xuzhou Medical University from January 2022 to January 2024.Patients were randomly divided into combined anesthesia group (thoracic paravertebralblock combined with generalanesthesia) and simple general anesthesia group (smple general anesthesia)， with 40 cases in each group. Plasma matrix metaloproteinase-9 (MMP-9)， lipoprotein-phospholipase A2 (Lp-PLA2)， interleukin-6 (IL-6) and tumor necrosis factor- α (TNF -α ) levels were compared between the two groups，and mini-mental state examination (MMSE) and event-related potential p300 were used to evaluate cognitive function in both groups.Result：Thelevels of MMP-9 ......