Impact and Research Progress of Permissible Hypercapnia on Postoperative Cognitive Dysfunctiol in Elderly Patients Undergoing Laparoscopic Surgery/MIN Xue， LYU Zhijian， LI Kongbing， JIA Yujie WANG Dongmei. //Medical Innovation of China， 2025， 22(10)： 183-188

    基金项目：青海大学附属医院(临床医学院)科学创新基金项目(FYXC-2024-06)

    通信作者：吕志坚

    [Abstract]In current medical practice， with the extensive application of laparoscopic technology in elderly patients， postoperative cognitive dysfunction (POCD)has become a key problem affecting the rehabilitation and quality of life of elderly patients. Permissible hypercapnia (PHC)is an acceptable respiratory acidosis resulting from theuse of low tidalvolume protective ventilationstrategies.Clinical studieshave shownthat theapplication of PHC in laparoscopic surgery can improve postoperative cognitive function in elderly patients through various mechanisms.It is important to note that although PHChas shown potential benefits in multiple studies， several key issues regarding its use inelderly patients remainunclear：first， the mechanismof overall effect of PHC on the physiological status ofelderly patients hasnot been fully elucidated； secondly ......