Effects of CYP2C19 and ApoE Gene Polymorphism Detection on Guiding Medication on Therapeutic Effect and Cognitive Function in Patients with Acute Cerebral Infarction/HUANG Jianfeng， YI Fei， ZHANG Lujiao， ZHONG Youyou. //Medical Innovation of China， 2025， 22(12)： 077-080

    [Abstract]Objective： To observe the efects of cytochrome P450 2C19 (CYP2C19) and apolipoprotein E (ApoE)gene polymorphism detectionon guiding medication ontherapeutic effect and cognitivefunction in patients with acute cerebral infarction (ACI).Method：A total of 80ACIpatients admitted to Pingxiang People's Hospital from September 2022 to February 2024 were selected and dividedintotwo groups according torandom number table method， with 40 cases in each group.The control group was given routine treatment， and the experimental group was given CYP2C19 and ApoE gene polymorphism detection to guide medication.Blood lipid indexes[low-density lipoprotein cholesterol (LDL-C)，high-densitylipoproteincholesterol (HDL-C)and total cholesterol (TC)]，ontreal cognitive assessment (MoCA)， modified Rankin scale (MRS)and national institutes of health stroke scale (NIHSS)scores and efficacy and adverse reactions were compared between the two groups before and after treatment.Result：Thetotalefectiverateofexperimentalgroupwashigherthanthatofcontrolgroup ......