Research Progress of Melatoninand Adipose Derived Stem Cells Transplantation for Spinal Cord Injury/TAN Weiyuan，ZHANG Wei，LI Qing，MA Tianyong.//Medical Innovation of China，2025，22(17)： 183-188

    [Abstract]Spinalcord injury is aserious traumatic disease in spinal surgery，and its occurrence mechanism is acomplex pathological process.At present，the treatment methods for spinal cord injury mainly include surgical treatment and non-surgical treatment.Surgical treatment includes anterior surgery，posterior surgeryand combined anterior surgery，and non-surgical treatment mainly includes drug therapy，hyperbaric oxygen therapy， etc.Melatonin，as a neurohormone，may promote the repair of spinal cord injury through mechanisms such as antioxidation，reducing inflammatory response，maintaining the integrityof the blood-spinal cord barrier，and maintaining microcirculation.Adipose derived stemcelsalso havearepairing efectonspinal cord injury，which maybe related to its mechanisms such as reducing inflammatory response and promoting angiogenesis.Melatonin and adipose derived stemcells transplantation are expected to become new efective treatment methods for spinal cord injury.Pretreatment ......