Observationonthe ClinicalEfectofClofazimineCombined with Bedaquiline inthe Treatmentof MDR-TB/YE Zaisheng，TANG Yuelian.//Medical Innovationof China，2025，22(17)： 052-056

    [Abstract]Objective：To explore the efects of Clofazimine combined with Bedaquilineon theratio of Mycobacterium tuberculosis specific antigen/phytohemagglutinin (TBAg/PHA)and soluble Tcell immunoglobulin mucinmolecule-3 (sTim-3) and retinol-binding protein-4(RBP-4) in patients with multi-drug resistant tuberculosis (MDR-TB).Method：Atotalof126patientswith MDR-TB intheFifth People's Hospitalof Ganzhou fromJanuary 2O22 to March 2O24 were selected.According tothe simplerandomnumber tablemethod，theresearch subjects were divided into the combined group，the Clofazimine group，andthe Bedaquiline group，with 42 cases in each group.All three groups adopted the conventional anti-tuberculosis regimens.On the basis of the above， the Clofazimine group received Clofazimine，the Bedaquiline group received Bedaquiline，and the combined group received Clofazimineand Bedaquiline.All were treated for6months.The therapeutic efects，the incidence of adverse reactionsand theratioof TBAg/PHA ......