Analysisof theEfficacyand Safetyof Entecavir SequentialPeginterferonalfa-2binthe Treatment of Chronic Hepatitis B/WUMinjuan，ZHANGYi，HUANG Maohui.//Medical Innovationof China，2025， 22(17)：005-009

    [Abstract]Objective：To investigate theefectofEntecavirsequential Peginterferonalfa-2b inthetreatment of chronic hepatitis B.Method：Eighty patients with chronic hepatitis B positive for hepatitis B surface antigen (HBsAg)who visited Shangrao People's Hospital from June to December 2023 wereselected，the patients were divided into the Entecavir group(n=40)and the sequential group (n=40)according to the simplified random grouping (odd-even number method).The Entecavir group was treated with Entecavir，whilethe sequential group was treated withEntecavir folowedbyPeginterferonalfa-2b.ThenormalizationratesofhepatitisBvirus (HBV)-DNA，hepatitis B surface antigen values andthe normalization rate of alanineaminotransferase (ALT)after treatment were compared betwen the two groups，Liverfunctionindicators[totalbileacid (TBA)，ALT，totalbilirubin(TBIL)]and liverfibrosis indicators [laminin (LN)， hyaluronic acid (HA) ......