Analysisof VaginalMicroecological Changes，SubtypeDistributionof HPVInfection inPatients with Cervical HSIL，and Influencing Factors of HPVOutcome/YUAN Aiqin，XUMeihua，YUJiamei.//Medical Innovation of China，2025，22(18)：157-162

    [Abstract]Objective：To explore the vaginal microecology changes and the subtype distribution of human papillma virus (HPV) infection in patients with cervical high-grade squamous intraepithelial lesion (HSIL)，and toanalyzethe influencing factorsofHPVoutcome.Method：A totalof15Opatients withcervical HSIL diagnosed bypathological examination inYichun Maternal and Child Health Center from January 2O21 to December 2022 were selected as the disease group，and another1OO healthy women who underwent physical examinations at the Outpatient Department durig the same period were selected as the control group.The disease group was divided into the HPV persistent infection group and the HPV negative conversion group based on whether HPV turned negative after one year of treatment.The vaginal microecology of the disease group and the control group was compared，thedistributionof high-risk HPV(HR-HPV)infectionsubtypes wasanalyzed ......