Study on the Effect and Safetyof in the Anticoagulation Treatment of Patients with CRRTat Bedside of ICU/WANGFei， WANG Jiawei，RAO Zonglin，LOU Wenshui，WANG Xiaoxiao，XU Zhongbo，XIA Wang，LIU Qunyan.//Medical Innovation of China，2025， 22(19)： 014-018

    [Abstract] Objective： To investigate the effect and safety of Nafamostat Mesylate in anticoagulant therapy for patients undergoing bedside continuous renal replacement therapy (CRRT) inthe ICU.Method： A total of 80 patients withbedside CRRT in the ICUofin Shangrao People's Hospital from June 2022 to June 2O24 were divided into control group 40O cases and observation group 4O cases by the random number table method. The control group was anticoagulated with Sodium Citrate，the observation group wasanticoagulated with Nafamostat Mesylate.The coagulationindexes (APTT，TT)，respiratoryandcirculatoryindexes(MAP，HRandSpO2)，liverandrenalfunction indexes (ALT，ASTandScr)and platelet activation indexes[plateletmembrane glycoprotein IIb(CD41)andP-selectin (CD62p)] at diffrent time，adverseevent rates of two groups were compared.Result： Before medication ......