联合检测抗瓜氨酸肽抗体与类风湿因子在类风湿关节炎中的诊断应用
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【摘要】目的探讨抗环瓜氨酸肽抗体(CCP)和类风湿因子(RF)联合检测在类风湿关节炎(RA)诊断中的应用价值。方法分别采用酶联免疫吸附法(ELISA)和免疫散射比浊法检测研究对象血清中抗CCP抗体和RF。结果RA组的抗CCP、RF及两者联合检测阳性率均明显高于非RA组和正常对照组，差异有统计学意义(P<0.01)；RA组患者中,抗CCP抗体诊断RA的敏感性较RF低，特异性却比RF高。抗CCP抗体和RF联合检测可提高诊断的敏感度和阴性预测值。结论 抗CCP抗体及RF具有较强的互补性，联合检测可提高RA与其他结缔组织疾病的鉴别诊断。
【关键词】抗瓜氨酸肽抗体；类风湿因子；类风湿关节炎
Examine the diagnostic significance by the detection anti- cyclic citrullinated peptide antibody and rheumatoid factor LIANG Xiu-yun. The Third Affiliated Hospital of Guangxi Medical University,Nanning 530031,China
【Abstract】ObjectiveTo examinethe diagnostic significance by detection anti-cyclic citrullinated peptide(CCP) antibody and rheumatoid factor(RF),and to examine the value in differentiating patients with rheumatoid arthritis (RA) from other rheumaticdiseases (non-RA).MethodsWe used enzyme-linked immunosorbent assay and rate nephelometry to detect CCP and RF in patientswith 87 RA,83 non-RA and 80 normal control group ......
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