钙剂联合rhBMP—2局部注射治疗老年骨质疏松性髋部骨折的效果及其安全性(1)
【摘要】 目的：探讨钙剂联合基因重组人骨形态蛋白-2(rhBMP-2)局部注射治疗老年骨质疏松性髋部骨折的效果及其安全性。方法：选取笔者所在医院2015年3月-2017年3月收治的老年骨质疏松性髋部骨折患者120例，按随机信封法分为观察组和对照组，每组60例。对照组在术后仅给予口服钙尔奇D治疗，观察组在其基础上联合rhBMP-2局部注射治疗，比较其治疗效果和不良反应发生情况。结果：观察组优良率、髋部骨密度(BMD)值高于对照组，髋关节恢复情况优于对照组，比较差异均有统计学意义(P<0.05)。治疗期间两组患者均未见严重不良反应。结论：钙剂联合rhBMP-2局部注射治疗老年骨质疏松性髋部骨折效果显著，安全性高。
【关键词】 老年骨质疏松性髋部骨折； 钙剂； 基因重组人骨形态蛋白-2； 疗效； 安全性
doi：10.14033/j.cnki.cfmr.2018.14.001 文献标识码 A 文章编号 1674-6805(2018)14-00-03
Effect Observation and Safety Analysis of Calcium Combined with rhBMP-2 Local Injection in the Treatment of Senile Osteoporotic Hip Fracture/LU Xiyan，RAO Luokui.//Chinese and Foreign Medical Research，2018，16(14)：10-12
【Abstract】 Objective：To investigate the efficacy and safety of Calcium combined with Recombinant Human Bone Morphogenetic Protein-2(rhBMP-2) injection in the treatment of osteoporotic hip fractures in the elderly.Method：From March 2015 to March 2017，120 elderly patients with osteoporotic hip fracture admitted to our hospital were selected and randomly divided into the observation group and the control group，with 60 cases in each group.The control group was only given oral Caltrate D treatment，the observation group combined with rhBMP-2 local injection therapy on the basis of the control group， the therapeutic effect and adverse reaction were observed.Result：The excellent and good rate and the hip bone mineral density(BMD) value of the observation group were higher than those of the control group，the hip joint recovery was better than that of the control group，and the differences were statistically significant(P<0.05).No serious adverse reactions were found in the two groups during the treatment.Conclusion：Calcium combined with rhBMP-2 local injection is effective and safe in the treatment of osteoporotic hip fracture in the elderly.
【Key words】 Osteoporotic hip fracture in the elderly； Calcium agent； Recombinant human bone morphogenetic protein -2； Curative effect； Security
First-author’s address：Xianfeng People’s Hospital，Xianfeng 445600，China
髋部骨折是指发生于股骨颈及股骨转子间的骨折，多见于老年人群，尤其多发于绝经后的妇女，随着我国人口老龄化加剧，老年髋部骨折的发病率也随之升高。患者骨折后的关节功能及日常生活能力明显下降，严重影响其生活质量甚至预期寿命[1]。骨质疏松性髋部骨折是一种危害力很大的骨折类型，其发病率、致残率和致死率均较高[2]。目前，该病主要采用外科手术联合药物治疗，以促进骨生长，抑制骨吸收，起到标本兼治的效果。骨形态生成蛋白(BMP)是一种从成年人骨组织中提取到的活性蛋白质，可使未分化的间充质细胞定向分化为骨细胞进而形成骨组织，临床上在骨折初期及骨缺损部位加入外源性BMP能提高局部BMP濃度，可用于难治性骨折、骨不连和骨缺损的治疗[3]。利用基因重组技术表达出rhBMP-2能成功的异位诱导出骨组织，并能在体外大量克隆，因而为BMP的大量应用创造了良好条件[4]。目前有关基因重组人骨形态蛋白-2(rhBMP-2)局部注射治疗老年骨质疏松性髋部骨折的研究较为少见，本研究就其治疗效果和安全性进行探讨，以期为临床应用提供科学依据，现报道如下。, 百拇医药(陆熙宴 饶洛逵)
【关键词】 老年骨质疏松性髋部骨折； 钙剂； 基因重组人骨形态蛋白-2； 疗效； 安全性
doi：10.14033/j.cnki.cfmr.2018.14.001 文献标识码 A 文章编号 1674-6805(2018)14-00-03
Effect Observation and Safety Analysis of Calcium Combined with rhBMP-2 Local Injection in the Treatment of Senile Osteoporotic Hip Fracture/LU Xiyan，RAO Luokui.//Chinese and Foreign Medical Research，2018，16(14)：10-12
【Abstract】 Objective：To investigate the efficacy and safety of Calcium combined with Recombinant Human Bone Morphogenetic Protein-2(rhBMP-2) injection in the treatment of osteoporotic hip fractures in the elderly.Method：From March 2015 to March 2017，120 elderly patients with osteoporotic hip fracture admitted to our hospital were selected and randomly divided into the observation group and the control group，with 60 cases in each group.The control group was only given oral Caltrate D treatment，the observation group combined with rhBMP-2 local injection therapy on the basis of the control group， the therapeutic effect and adverse reaction were observed.Result：The excellent and good rate and the hip bone mineral density(BMD) value of the observation group were higher than those of the control group，the hip joint recovery was better than that of the control group，and the differences were statistically significant(P<0.05).No serious adverse reactions were found in the two groups during the treatment.Conclusion：Calcium combined with rhBMP-2 local injection is effective and safe in the treatment of osteoporotic hip fracture in the elderly.
【Key words】 Osteoporotic hip fracture in the elderly； Calcium agent； Recombinant human bone morphogenetic protein -2； Curative effect； Security
First-author’s address：Xianfeng People’s Hospital，Xianfeng 445600，China
髋部骨折是指发生于股骨颈及股骨转子间的骨折，多见于老年人群，尤其多发于绝经后的妇女，随着我国人口老龄化加剧，老年髋部骨折的发病率也随之升高。患者骨折后的关节功能及日常生活能力明显下降，严重影响其生活质量甚至预期寿命[1]。骨质疏松性髋部骨折是一种危害力很大的骨折类型，其发病率、致残率和致死率均较高[2]。目前，该病主要采用外科手术联合药物治疗，以促进骨生长，抑制骨吸收，起到标本兼治的效果。骨形态生成蛋白(BMP)是一种从成年人骨组织中提取到的活性蛋白质，可使未分化的间充质细胞定向分化为骨细胞进而形成骨组织，临床上在骨折初期及骨缺损部位加入外源性BMP能提高局部BMP濃度，可用于难治性骨折、骨不连和骨缺损的治疗[3]。利用基因重组技术表达出rhBMP-2能成功的异位诱导出骨组织，并能在体外大量克隆，因而为BMP的大量应用创造了良好条件[4]。目前有关基因重组人骨形态蛋白-2(rhBMP-2)局部注射治疗老年骨质疏松性髋部骨折的研究较为少见，本研究就其治疗效果和安全性进行探讨，以期为临床应用提供科学依据，现报道如下。, 百拇医药(陆熙宴 饶洛逵)