结缔组织病合并真菌性食管炎42例临床分析及文献回顾(1)
【摘要】 目的：探討结缔组织病合并真菌性食管炎的临床特征、易患因素及治疗情况。方法：回顾性分析福建省立医院风湿免疫科2005年1月-2018年10月住院的42例结缔组织病合并真菌性食管炎患者的临床资料，分别随机选取同期确诊为真菌性食管炎的非结缔组织病患者40例及未合并真菌性食管炎的结缔组织病患者40例作为对照组。分析临床特点。结果：与非结缔组织病的真菌性食管炎相比，结缔组织病合并真菌性食管炎的患者中无症状者所占比例明显较多(分别为64.3% 和20.0%)，差异有统计学意义(P<0.001);Ⅲ～Ⅳ级食管炎的比例明显较高(分别为52.4%和27.5%)，差异有统计学意义(P=0.026);相同治疗时间下，真菌性食管炎的治愈率也较低。与未合并真菌性食管炎的结缔组织病患者相比较，合并真菌性食管炎的结缔组织病患者，其激素剂量明显较高，分别为强的松[(22.77±2.30)mg/d和(15.83±2.01)mg/d]，差异有统计学意义(P=0.029)。结论：结缔组织病合并真菌性食管炎常无明显症状，但病情相对较重。激素剂量高的结缔组织病患者，发生真菌性食管炎的风险增加。治疗上需要足疗程甚至适当延长疗程。
【关键词】 结缔组织病; 真菌性食管炎; 激素
doi：10.14033/j.cnki.cfmr.2019.10.076 文献标识码 B 文章编号 1674-6805(2019)10-0-04
Clinical Analysis and Literature Review of 42 Cases of Connective Tissue Disease Complicated with Mycotic Esophagitis/DAI Yijun，YAN Qing，GAO Fei，et al.//Chinese and Foreign Medical Research，2019，17(10)：157-160
【Abstract】 Objective：To analyze the clinical features，risk factor and outcome of connective tissue disease complicated with mycotic esophagitis.
Method：Forty-two connective tissue disease complicated with mycotic esophagitis patients in Department of Rheumatology and Immunology，Fujian Provincial Hospital from January 2005 to October 2018 were retrospectively analyzed.Forty mycotic esophagitis without connective tissue disease patients and forty connective tissue disease patients without mycotic esophagitis were enrolled as control groups.The clinical characters were analyzed.Result：In connective tissue disease complicated with mycotic esophagitis group，the ratio of asymptotic patients were significantly higher than mycotic esophagitis without connective tissue disease group(64.3% vs 20.0%，retrospectively)，the difference was statistically significant(P<0.001);while the ratio of grade Ⅲ～Ⅳesophagitis were significantly higher(52.4% vs 27.5%，retrospectively)，the difference was statistically significant(P=0.026).The cure rate was lower than mycotic esophagitis without connective tissue disease group under the same therapy period.Compared with patients with connective tissue disease but without mycotic esophagitis，the prednisone dosage in connective tissue disease complicated with mycotic esophagitis group was significantly higher，which was (22.77±2.30)mg/d and (15.83±2.01)mg/d，retrospectively，and the difference was statistically significant(P=0.029).Conclusion：Connective tissue disease complicated with mycotic esophagitis is often asymptomatic but in a worse situation.For connective tissue disease patients receiving high dosage of steroid，the risk of mycotic esophagitis is increased.The treatment period should be adequate or even longer., http://www.100md.com(戴逸君 严青 高飞 林禾)
【关键词】 结缔组织病; 真菌性食管炎; 激素
doi：10.14033/j.cnki.cfmr.2019.10.076 文献标识码 B 文章编号 1674-6805(2019)10-0-04
Clinical Analysis and Literature Review of 42 Cases of Connective Tissue Disease Complicated with Mycotic Esophagitis/DAI Yijun，YAN Qing，GAO Fei，et al.//Chinese and Foreign Medical Research，2019，17(10)：157-160
【Abstract】 Objective：To analyze the clinical features，risk factor and outcome of connective tissue disease complicated with mycotic esophagitis.
Method：Forty-two connective tissue disease complicated with mycotic esophagitis patients in Department of Rheumatology and Immunology，Fujian Provincial Hospital from January 2005 to October 2018 were retrospectively analyzed.Forty mycotic esophagitis without connective tissue disease patients and forty connective tissue disease patients without mycotic esophagitis were enrolled as control groups.The clinical characters were analyzed.Result：In connective tissue disease complicated with mycotic esophagitis group，the ratio of asymptotic patients were significantly higher than mycotic esophagitis without connective tissue disease group(64.3% vs 20.0%，retrospectively)，the difference was statistically significant(P<0.001);while the ratio of grade Ⅲ～Ⅳesophagitis were significantly higher(52.4% vs 27.5%，retrospectively)，the difference was statistically significant(P=0.026).The cure rate was lower than mycotic esophagitis without connective tissue disease group under the same therapy period.Compared with patients with connective tissue disease but without mycotic esophagitis，the prednisone dosage in connective tissue disease complicated with mycotic esophagitis group was significantly higher，which was (22.77±2.30)mg/d and (15.83±2.01)mg/d，retrospectively，and the difference was statistically significant(P=0.029).Conclusion：Connective tissue disease complicated with mycotic esophagitis is often asymptomatic but in a worse situation.For connective tissue disease patients receiving high dosage of steroid，the risk of mycotic esophagitis is increased.The treatment period should be adequate or even longer., http://www.100md.com(戴逸君 严青 高飞 林禾)