药物性鼻炎应用糠酸莫米松鼻喷雾剂治疗效果分析(1)
【摘要】 目的：探讨药物性鼻炎应用糠酸莫米松鼻喷雾剂治疗的效果及安全性。方法：选取药物性鼻炎患者68例，按照随机数字表法，分为对照组(n=34)与研究组(n=34)。对照组接受常规药物治疗，观察组接受糠酸莫米松鼻喷雾剂治疗，比较两组临床疗效、鼻塞改善情况及不良反应发生率。结果：研究组治疗总有效率为91.18%，高于对照组的73.53%，差异有统计学意义(P<0.05)。研究组治疗后鼻塞评分低于对照组，鼻塞消失时间早于对照组，差异均有统计学意义(P<0.05)。研究组不良反应发生率低于对照组，差异有统计学意义(P<0.05)。结论：糠酸莫米松鼻喷雾剂可有效治疗药物性鼻炎，促使患者鼻塞症状改善及消失，且可有效减少不良反应的发生，具备较高的应用安全性。
【关键词】 药物性鼻炎; 糠酸莫米松鼻喷雾剂; 临床疗效; 鼻塞; 不良反应
doi：10.14033/j.cnki.cfmr.2019.25.063 文献标识码 B 文章编号 1674-6805(2019)25-0-03
Therapeutic Effect of Mometasone Furoate Nasal Spray on Drug-induced Rhinitis/CHEN Yuping，LI Qixing.//Chinese and Foreign Medical Research，2019，17(25)：-150
【Abstract】 Objective：To investigate the efficacy and safety of Mometasone Furoate Nasal Spray in the treatment of drug-induced rhinitis.Method：A total of 68 patients with drug-induced rhinitis were selected and divided into control group(n=34) and study group(n=34) according to the random number table method.The control group received conventional drug treatment，and the observation group received Mometasone Furoate Nasal Spray.The clinical efficacy，nasal congestion improvement and adverse reaction rate were compared between the two groups.Result：The total effective rate of the study group was 91.18%，which was higher than 73.53% of the control group，the difference was statistically significant(P<0.05).The nasal congestion score of the study group was lower than that of the control group，and the nasal congestion disappeared earlier than that of the control group，the differences were statistically significant(P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group，the difference was statistically significant(P<0.05).Conclusion：Mometasone Furoate Nasal Spray can effectively treat drug-induced rhinitis，improve the symptoms of nasal congestion and disappear，and can effectively reduce the occurrence of adverse reactions，with high application safety.
【Key words】 Drug-induced rhinitis; Mometasone Furoate Nasal Spray; Clinical efficacy; Nasal obstruction; Adverse reactions
First-author’s address：Fuzhou Second Hospital Affiliated to Xiamen University，Fuzhou 350000，China
药物性鼻炎是由于长期滥用鼻减充血剂导致机体鼻黏膜发生慢性中毒反应，也被称作“中毒性鼻炎”或“反跳性鼻炎”，同时有资料报道称，长期应用利血平、新斯的明等药物也可能导致药物性鼻炎的发生[1]。鼻减充血剂属于非处方类药物，因此鼻炎患者自感不适时可自行购买用药，其虽可使鼻塞症状得到暂时缓解，但会导致患者出现药物依赖性，增加鼻腔负担[2]。藥物性鼻炎不仅会导致鼻黏膜发生充血水肿，同时也会产生大量黏性分泌物，由此影响呼吸功能，持续性炎症会致使鼻腔与咽部出现干燥不适症状。糠酸莫米松鼻喷雾剂属于糖皮质激素药物，其可局部用药，不良反应少。有资料报道称，糠酸莫米松鼻喷雾剂在应变性鼻炎治疗中应用效果较好。但对于其在药物性鼻炎中的研究报道并不多[3]。本次研究就选取药物性鼻炎患者68例，探讨药物性鼻炎应用糠酸莫米松鼻喷雾剂治疗的效果及安全性，现报告如下。, http://www.100md.com(陈瑜萍 李其兴)
【关键词】 药物性鼻炎; 糠酸莫米松鼻喷雾剂; 临床疗效; 鼻塞; 不良反应
doi：10.14033/j.cnki.cfmr.2019.25.063 文献标识码 B 文章编号 1674-6805(2019)25-0-03
Therapeutic Effect of Mometasone Furoate Nasal Spray on Drug-induced Rhinitis/CHEN Yuping，LI Qixing.//Chinese and Foreign Medical Research，2019，17(25)：-150
【Abstract】 Objective：To investigate the efficacy and safety of Mometasone Furoate Nasal Spray in the treatment of drug-induced rhinitis.Method：A total of 68 patients with drug-induced rhinitis were selected and divided into control group(n=34) and study group(n=34) according to the random number table method.The control group received conventional drug treatment，and the observation group received Mometasone Furoate Nasal Spray.The clinical efficacy，nasal congestion improvement and adverse reaction rate were compared between the two groups.Result：The total effective rate of the study group was 91.18%，which was higher than 73.53% of the control group，the difference was statistically significant(P<0.05).The nasal congestion score of the study group was lower than that of the control group，and the nasal congestion disappeared earlier than that of the control group，the differences were statistically significant(P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group，the difference was statistically significant(P<0.05).Conclusion：Mometasone Furoate Nasal Spray can effectively treat drug-induced rhinitis，improve the symptoms of nasal congestion and disappear，and can effectively reduce the occurrence of adverse reactions，with high application safety.
【Key words】 Drug-induced rhinitis; Mometasone Furoate Nasal Spray; Clinical efficacy; Nasal obstruction; Adverse reactions
First-author’s address：Fuzhou Second Hospital Affiliated to Xiamen University，Fuzhou 350000，China
药物性鼻炎是由于长期滥用鼻减充血剂导致机体鼻黏膜发生慢性中毒反应，也被称作“中毒性鼻炎”或“反跳性鼻炎”，同时有资料报道称，长期应用利血平、新斯的明等药物也可能导致药物性鼻炎的发生[1]。鼻减充血剂属于非处方类药物，因此鼻炎患者自感不适时可自行购买用药，其虽可使鼻塞症状得到暂时缓解，但会导致患者出现药物依赖性，增加鼻腔负担[2]。藥物性鼻炎不仅会导致鼻黏膜发生充血水肿，同时也会产生大量黏性分泌物，由此影响呼吸功能，持续性炎症会致使鼻腔与咽部出现干燥不适症状。糠酸莫米松鼻喷雾剂属于糖皮质激素药物，其可局部用药，不良反应少。有资料报道称，糠酸莫米松鼻喷雾剂在应变性鼻炎治疗中应用效果较好。但对于其在药物性鼻炎中的研究报道并不多[3]。本次研究就选取药物性鼻炎患者68例，探讨药物性鼻炎应用糠酸莫米松鼻喷雾剂治疗的效果及安全性，现报告如下。, http://www.100md.com(陈瑜萍 李其兴)
参见：首页 > 医疗版 > 疾病专题 > 耳鼻喉科 > 鼻及鼻窦疾病 > 鼻腔疾病 > 鼻炎