普罗布考联合乐脉丸对老年高血压患者动脉硬化的影响 ?(1)
【摘要】 目的：探討普罗布考联合乐脉丸对老年高血压患者动脉硬化的影响。方法：本研究采用对照、单盲、随机分组的方法。以2016年1月-2017年10月笔者所在医院心内科门诊及住院老年高血压患者90例为研究对象，排除60岁以下及非高血压患者。将研究对象随机分为三组，阿托伐他汀组(对照组)30例，治疗1组30例在对照组基础上加用普罗布考，治疗2组30例在对照组基础上加用普罗布考及乐脉丸。分别检测治疗初始、18个月后各组动脉硬化指标，包括臂-踝脉搏波传导速度(baPWV)、踝臂指数(ABI)、颈动脉斑块厚度、颈动脉斑块硬度、脉压差。比较治疗初始与18个月后组内各指标的差异及治疗18个月后组间各指标的差异。结果：两治疗组治疗初始与18个月后ABI比较差异无统计学意义(P>0.05)，其余各指标治疗18个月后优于治疗初始，差异均有统计学意义(P<0.05)。治疗18个月后两治疗组ABI与对照组比较，差异无统计学意义(P>0.05)，其余各指标两治疗组优于对照组，差异均有统计学意义(P<0.05);治疗1组与治疗2组比较，治疗2组颈动脉斑块硬度优于治疗1组，差异有统计学意义(P<0.05)，其余指标差异无统计学意义(P>0.05)。在治疗2组，颈动脉斑厚度、脉压差与治疗时间呈负相关，颈动脉硬斑例数与治疗时间呈正相关。结论：普罗布考联合乐脉丸能有效治疗动脉硬化，联合阿托伐他汀，治疗时间越长，效果越显著。
【关键词】 普罗布考 乐脉丸 高血压 动脉硬化
[Abstract] Objective： To investigate the effect of Probucol joint Lemai Pill on arteriosclerosis in elderly patients with hypertension. Method： The study was in the way of control， single-blind， randomized approach. From January 2016 to October 2017， 90 elderly hypertensive patients from cardiac outpatient and inpatients in our hospital were selected. Excluding patients under 60 and non-hypertensive. The study subjects were randomly divided into three groups， 30 patients in the atorvastatin control group， treatment of 30 cases in group 1 was addition of Probucol based on the control group， treatment of 30 cases in group 2 was addition of Probucol and Lemai Pill based on the control group. The arm-ankle pulse wave velocity (baPWV)， ankle-brachial index (ABI)， carotid plaque thickness， carotid plaque hardness， and pulse pressure difference were measured in each group at the beginning and 18 months after treatment. The difference between the indexes in the group after the initial treatment and 18 months were compared， and the difference between the indexes in the group after the 18 months of treatment were compared. Result： There were no significant difference in ABI between the initial treatment and 18 months after treatment in two treatment groups (P>0.05)， and the other indicators 18 months treatment after were better than the initial treatment， there were statistical differences (P<0.05). Comparison between the groups after 18 months of treatment， there was no significant difference in ABI between the two treatment groups and the control group (P>0.05)， and the other indicators in two treatment groups were better than those in the control group (P<0.05). Compared with treatment group 1 and treatment group 2， carotid plaque hardness in the treatment group 2 was better than group 1， there was a statistically significant difference (P<0.05)， and there was no statistical difference in the other indicators (P>0.05). In treatment group 2， the carotid plaque thickness and pulse pressure difference were negatively correlated with the treatment time， and the number of carotid plaques was positively correlated with the treatment time. Conclusion： Probucol joint Lemai Pills can effectively treat arteriosclerosis. In combination with atorvastatin， the longer the treatment time， the more significant the effect., http://www.100md.com(龚武田 石卫晨 兰永乔)
【关键词】 普罗布考 乐脉丸 高血压 动脉硬化
[Abstract] Objective： To investigate the effect of Probucol joint Lemai Pill on arteriosclerosis in elderly patients with hypertension. Method： The study was in the way of control， single-blind， randomized approach. From January 2016 to October 2017， 90 elderly hypertensive patients from cardiac outpatient and inpatients in our hospital were selected. Excluding patients under 60 and non-hypertensive. The study subjects were randomly divided into three groups， 30 patients in the atorvastatin control group， treatment of 30 cases in group 1 was addition of Probucol based on the control group， treatment of 30 cases in group 2 was addition of Probucol and Lemai Pill based on the control group. The arm-ankle pulse wave velocity (baPWV)， ankle-brachial index (ABI)， carotid plaque thickness， carotid plaque hardness， and pulse pressure difference were measured in each group at the beginning and 18 months after treatment. The difference between the indexes in the group after the initial treatment and 18 months were compared， and the difference between the indexes in the group after the 18 months of treatment were compared. Result： There were no significant difference in ABI between the initial treatment and 18 months after treatment in two treatment groups (P>0.05)， and the other indicators 18 months treatment after were better than the initial treatment， there were statistical differences (P<0.05). Comparison between the groups after 18 months of treatment， there was no significant difference in ABI between the two treatment groups and the control group (P>0.05)， and the other indicators in two treatment groups were better than those in the control group (P<0.05). Compared with treatment group 1 and treatment group 2， carotid plaque hardness in the treatment group 2 was better than group 1， there was a statistically significant difference (P<0.05)， and there was no statistical difference in the other indicators (P>0.05). In treatment group 2， the carotid plaque thickness and pulse pressure difference were negatively correlated with the treatment time， and the number of carotid plaques was positively correlated with the treatment time. Conclusion： Probucol joint Lemai Pills can effectively treat arteriosclerosis. In combination with atorvastatin， the longer the treatment time， the more significant the effect., http://www.100md.com(龚武田 石卫晨 兰永乔)
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