闭合式鼻咽冲洗法对鼻咽癌放疗患者鼻咽分泌物黏稠度的影响(1)
【摘要】 目的：探讨闭合式鼻咽冲洗法对鼻咽癌放疗患者鼻咽分泌物黏稠度的影响。方法：选取笔者所在医院2018年1月-2019年7月收治的鼻咽癌放疗患者共60例，按照随机数字法分为对照组(采用开放式鼻腔冲洗法)和观察组(采用闭合式鼻咽冲洗法)，两组均为30例。比较两组鼻咽分泌物黏稠度、鼻黏膜损伤情况及生活质量。结果：治疗后，观察组鼻咽分泌物黏稠程度优于对照组(P<0.05);观察组鼻咽鼻黏膜损伤改善程度优于对照组(P<0.05);观察组放疗中期与后期生活质量评分明显低于对照组(P<0.05)。结论：闭合式鼻咽冲洗法应用于鼻咽癌放疗患者中能够降低分泌物黏稠度和鼻黏膜受损程度，生活质量降低得更慢，值得临床推广。
【关键词】 鼻咽癌 鼻腔冲洗法 放疗 鼻咽分泌物黏稠度
doi：10.14033/j.cnki.cfmr.2020.23.051 文献标识码 B 文章编号 1674-6805(2020)23-0-03
Effect of Closed Nasopharyngeal Irrigation on the Viscosity of Nasopharyngeal Secretions in Patients Undergoing Radiotherapy for Nasopharyngeal Carcinoma/CHEN Xun. //Chinese and Foreign Medical Research， 2020， 18(23)： -130
[Abstract] Objective： To investigate the effect of closed nasopharyngeal irrigation on the viscosity of nasopharyngeal secretions in patients with nasopharyngeal carcinoma undergoing radiotherapy. Method： A total of 60 patients with nasopharyngeal carcinoma treated by radiotherapy in our hospital from January 2018 to July 2019 were selected and divided into the control group (using open nasal irrigation method) and the observation group (using closed nasopharyngeal irrigation method) according to random number method， with 30 cases in both groups. The nasopharyngeal secretion viscosity， nasal mucosal injury and quality of life were compared between the two groups. Result： After treatment， the nasopharyngeal secretion viscosity in the observation group was better than that in the control group (P<0.05). The nasopharyngeal mucosal injury in the observation group was better than that in the control group (P<0.05). The quality of life scores in the middle and late stages of radiotherapy in the observation group were significantly lower than those in the control group (P<0.05). Conclusion： The closed nasopharyngeal irrigation method used in patients with nasopharyngeal cancer radiotherapy can reduce the viscosity of secretions and the degree of damage to the nasal mucosa， and the quality of life will decrease more slowly. It is worthy of clinical promotion.
[Key words] Nasopharyngeal carcinoma Nasal irrigation Radiotherapy Nasopharyngeal secretion viscosity
First-author’s address： First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine， Guangzhou 510405， China
鼻咽癌居于頭颈部恶性肿瘤的首位，主要以放疗为主，随着放疗的持续进行，易引起鼻咽分泌物黏稠、鼻黏膜损伤等并发症的发生，而鼻腔冲洗可以起到改善作用[1]。临床上主要以球囊式鼻腔冲洗器来进行开放式冲洗，其操作简单，携带方便，但不易控制冲洗时的压力，且难以冲洗到鼻咽部，在降低鼻咽分泌物黏稠度方面效果欠佳[2]。闭合式鼻咽冲洗法采用双正压返回流技术，使冲洗液在进行冲洗时的水流恒压平稳，单向进入鼻腔及鼻咽部，使冲洗液能够浸润整个鼻腔，可能有利于改善分泌物的黏稠度[3]。为使鼻咽癌放疗患者鼻咽分泌物的黏稠度降低，提高其生活质量，本研究旨在探讨闭合式鼻咽冲洗法对鼻咽癌放疗患者鼻咽分泌物黏稠度的影响，现报告如下。, 百拇医药(陈询)
【关键词】 鼻咽癌 鼻腔冲洗法 放疗 鼻咽分泌物黏稠度
doi：10.14033/j.cnki.cfmr.2020.23.051 文献标识码 B 文章编号 1674-6805(2020)23-0-03
Effect of Closed Nasopharyngeal Irrigation on the Viscosity of Nasopharyngeal Secretions in Patients Undergoing Radiotherapy for Nasopharyngeal Carcinoma/CHEN Xun. //Chinese and Foreign Medical Research， 2020， 18(23)： -130
[Abstract] Objective： To investigate the effect of closed nasopharyngeal irrigation on the viscosity of nasopharyngeal secretions in patients with nasopharyngeal carcinoma undergoing radiotherapy. Method： A total of 60 patients with nasopharyngeal carcinoma treated by radiotherapy in our hospital from January 2018 to July 2019 were selected and divided into the control group (using open nasal irrigation method) and the observation group (using closed nasopharyngeal irrigation method) according to random number method， with 30 cases in both groups. The nasopharyngeal secretion viscosity， nasal mucosal injury and quality of life were compared between the two groups. Result： After treatment， the nasopharyngeal secretion viscosity in the observation group was better than that in the control group (P<0.05). The nasopharyngeal mucosal injury in the observation group was better than that in the control group (P<0.05). The quality of life scores in the middle and late stages of radiotherapy in the observation group were significantly lower than those in the control group (P<0.05). Conclusion： The closed nasopharyngeal irrigation method used in patients with nasopharyngeal cancer radiotherapy can reduce the viscosity of secretions and the degree of damage to the nasal mucosa， and the quality of life will decrease more slowly. It is worthy of clinical promotion.
[Key words] Nasopharyngeal carcinoma Nasal irrigation Radiotherapy Nasopharyngeal secretion viscosity
First-author’s address： First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine， Guangzhou 510405， China
鼻咽癌居于頭颈部恶性肿瘤的首位，主要以放疗为主，随着放疗的持续进行，易引起鼻咽分泌物黏稠、鼻黏膜损伤等并发症的发生，而鼻腔冲洗可以起到改善作用[1]。临床上主要以球囊式鼻腔冲洗器来进行开放式冲洗，其操作简单，携带方便，但不易控制冲洗时的压力，且难以冲洗到鼻咽部，在降低鼻咽分泌物黏稠度方面效果欠佳[2]。闭合式鼻咽冲洗法采用双正压返回流技术，使冲洗液在进行冲洗时的水流恒压平稳，单向进入鼻腔及鼻咽部，使冲洗液能够浸润整个鼻腔，可能有利于改善分泌物的黏稠度[3]。为使鼻咽癌放疗患者鼻咽分泌物的黏稠度降低，提高其生活质量，本研究旨在探讨闭合式鼻咽冲洗法对鼻咽癌放疗患者鼻咽分泌物黏稠度的影响，现报告如下。, 百拇医药(陈询)