自拟中药方剂治疗原发性痛风性肾病的效果分析(1)
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【摘要】 目的观察自拟中药方剂治疗原发性痛风性肾病的效果。方法将我院80例原发性痛风性肾病患者随机分为治疗组及对照组，对照组患者口服别嘌呤醇，治疗组患者服用自拟中药方剂。结果经过治疗，治疗组的总有效率为85.0%，显著高于对照组的70.0%，差异有统计学意义(P<0.05)。两组患者治疗后UA、Cre、UN、β2-M、24 h 尿蛋白与治疗前比较均有显著减少(P<0.05)，治疗组Cre、UN、β2- M、24 h 尿蛋白改善更加明显，与对照组比较，差异有统计学意义(P<0.05)。治疗组3例出现大便过稀，对照组有4例出现不同程度的恶心、胃肠不适等反应，均自行好转，未发现其他严重不良反应。结论采用本方治疗原发性痛风性肾病能明显改善肾功能、降低蛋白尿、促进毒物排泄的作用，且无不良反应，具有一定的可行性和研究价值。
【关键词】 中药；肾病；原发性痛风性肾病
self-made traditional Chinese medicine treatment primary gouty nephropathy effectiveness analysis
【Abstract】 Objective observed self-made traditional Chinese medicine treatment primary gouty nephropathy effectiveness. Methods 80 cases of primary gouty nephropathy were randomly divided into treatment group and control group In our hospital, control group patients were treated with allopurinol, treatment group taking the self-made traditional Chinese medicine prescriptions. Results After treatment, the treatment group, the total effective rate was 85.0%, significantly higher than the 70.0%, the difference was statistically significant (P <0.05). Two groups of patients after treatment UA, Cre, UN, β2-M, 24 h urinary protein compared with before treatment were significantly reduced (P <0.05), Two groups of patients after treatment UA, Cre, UN, β2-M, 24 h urinary protein compared with before treatment were significantly reduced (P <0.05), 3 patients had thin stool in the treatment group, 4 patients had varying degrees of nausea, gastrointestinal discomfort reaction in the control group, are all self-improvement, did not find other serious adverse reactions.Conclusion self-made traditional Chinese medicine treatment primary gouty nephropathy can significantly improve renal function and reduce proteinuria, and promote excretion of toxic effect, and no adverse reactions, and study the feasibility of a certain value.
【Key words】 traditional Chinese medicine; kidney disease; primary gouty nephropathy
痛风性肾病又称慢性尿酸性肾病，是由于体内嘌呤代谢紊乱，血尿酸升高，使尿酸沉积于肾脏所致的疾病。近年来随着人民生活水平的提高、饮食结构的变化，该病发病率也随之呈上升趋势。西医治疗虽然疗效比较确切，但易复发，目前国内学者已着眼于从中医药寻求疗效好、副反应少的药物，取得了一定的进展[1]。我院自2008年6月～2010年6月对收治的原发性痛风性肾病患者采用自拟中药方剂治疗，效果较好，现将结果，报告如下。
1 资料与方法
1.1 一般资料 80例患者均为我院收治的原发性痛风性肾病患者 ......
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