摘要：目的：探讨和总结53例人类白细胞抗原(HLA)半相合异基因骨髓造血干细胞移植(Allo-PBSCT)治疗重型再生障碍性贫血(SAA)病人的护理。方法 对53例移植患者进行心理干预、造血干细胞回输、移植后移植物抗宿主病 (GVHD) 及相关并发症护理。结果 53例患者均配合治疗和护理，出现的焦虑、抑郁情绪程度轻，经心理干预均缓解。均获造血重建，经检测HLA为供者型。出现2 例皮肤急性 GVHD，1 例肠道急性 GVHD，1 例上呼吸道感染，3例口腔粘膜溃疡，1 例出血性膀胱炎。经积极对症处理和精心护理症状明显缓解。结论 结论 HLA半相合Allo-PBSCT患者移植过程中的护理干预对提高移植成功率有重要作用。

    关键词：重型再生障碍性贫血;异基因造血干细胞移植;护理

    [Abstract] Objective To investigate and summarize the nursing of 53 patients with severe aplastic anemia (SAA) treated with human leukocyte antigen (HLA) haploidentical bone marrow hematopoietic stem cell transplantation (Allo-PBSCT). Methods 53 patients with transplantation were treated with psychological intervention， hematopoietic stem cell reinfusion， graft-versus-host disease (GVHD) and related complications. Results All the 53 patients were treated with treatment and nursing. The anxiety and depression were mild and alleviated by psychological intervention. Hematopoietic reconstitution was performed， and HLA was tested as donor type. There were 2 cases of acute skin GVHD， 1 case of acute intestinal GVHD， 1 case of upper respiratory tract infection ......