常用抗肿瘤药物基因组学研究进展(4)
[16] Pullarkat S，Stoehlmacher J，Ghaderi V，et al.Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy[J].Pharmacogenomics，2001，1：65-70.
[17] Lecomte T，Ferraz J，Zinzindohoue F，et al.Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy[J]. Clin Cancer Res，2004，10：5880-5888.
[18] Etienne-Grimaldi M，Francoual M，Formento J，et al. Methylenetetrahydrofolate reductase (MTHFR) variants and fluorouracil-based treatments in colorectal cancer[J].Pharmacogenomics，2007，8：1561-1566.
[19] Fleming R，Milano G，Thyss A，et al.Correlation between dihydropyrimidine dehydrogenase activity in peripheral mononuclear cells and systemic clearance of fluorouracil in cancer patients[J].Cancer Res，1992，52：2899-2902.
[20] Iyer L，King C，Whitington P，et al.Genetic predisposition to the metabolism of irinotecan (CPT-11).Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes[J].J Clin Invest，1998，101：847-854.
(收稿日期：2013-10-02), http://www.100md.com(郝志英 李云娥)
[17] Lecomte T，Ferraz J，Zinzindohoue F，et al.Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy[J]. Clin Cancer Res，2004，10：5880-5888.
[18] Etienne-Grimaldi M，Francoual M，Formento J，et al. Methylenetetrahydrofolate reductase (MTHFR) variants and fluorouracil-based treatments in colorectal cancer[J].Pharmacogenomics，2007，8：1561-1566.
[19] Fleming R，Milano G，Thyss A，et al.Correlation between dihydropyrimidine dehydrogenase activity in peripheral mononuclear cells and systemic clearance of fluorouracil in cancer patients[J].Cancer Res，1992，52：2899-2902.
[20] Iyer L，King C，Whitington P，et al.Genetic predisposition to the metabolism of irinotecan (CPT-11).Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes[J].J Clin Invest，1998，101：847-854.
(收稿日期：2013-10-02), http://www.100md.com(郝志英 李云娥)