两种左氧氟沙星用药方案治疗社区获得性肺炎的疗效分析(1)
[摘要] 目的 分析两种左氧氟沙星用药方案治疗社区获得性肺炎(CAP)的临床疗效。 方法 分析我院自2012年6月～2014年6月收治的164例社区获得性肺炎的患者，随机分为对照组82例，给予静脉滴注左氧氟沙星；治疗组82例，在对照组的基础上，静脉治疗结束后，口服左氧氟沙星片。比较两组临床症状的改变、临床疗效和不良反应。 结果 治疗组与对照组在咳嗽、发热、肺部啰音、白细胞计数比较，差异有统计学意义(t=2.014，2.043，2.013，2.001，P<0.05)；对照组与治疗组临床总有效率分别为80.48%(66/82)， 97.56%(80/82)，两组比较差异有统计学意义(x2=12.231，P<0.05)；对照组与治疗组不良反应发生率分别为4.9%(4/82)、9.8%(8/82)，两组比较差异有统计学意义(x2=1.439，P>0.05)。结论 左氧氟沙星注射液与片剂序贯疗法治疗CAP可有效改善临床症状，安全性好，同时不增加不良反应的发生率，有临床推广应用的价值。
[关键词] 社区获得性肺炎；左氧氟沙星；序贯；疗效；症状；不良反应
[中图分类号] R563.1 [文献标识码] B [文章编号] 2095-0616(2015)06-38-03
Analysis of curative effect of two kinds of levofloxacin regimen in the treatment of community acquired pneumonia
LI Qiuquan1 LIU Kequan2 WANG Xiaoming 3
1.Department of Community Health，Nanhai Luocun Hospital of Foshan City， Foshan 528226，China；2. Department of Internal Medicine， Nanhai Luocun Hospital of Foshan City， Foshan 528226，China；3.ICU， Nanhai Luocun Hospital of Foshan City， Foshan 528226，China
[Abstract] Objective To analyze the curative effect of two kinds of levofloxacin regimen in the treatment of community acquired pneumoni(CAP). Methods 164 cases of community acquired pneumonia in our hospital from 2012 June to 2014 June were analyzed and randomly divided into the control group(82 cases)，which was given intravenous levofloxacin，and the treatment group(82 cases)which was given oral Levofloxacin Tablets on the basis of the control group after intravenous treatment.The clinical symptoms change， clinical efficacy and adverse reactions of two groups were compared with each other. Results There were statistically significant differences between the two groups in the cough， fever， pulmonary rales， leucocyte count(t=2.014，2.043，2.013， 2.001； P< 0.05)；The total clinical effective rates between the control group and the treatment group were 80.48%(66/82)， 97.56%(80/82)，the difference was statistical significance (x2=12.231，P<0.05)；The incidences of adverse reactions were 4.9% (4/82)， 9.8% (8/82)， there was significant difference between the two groups (x2=1.439，P> 0.05). Conclusion The clinical curative effect of sequential therapy of levofloxacin of injection and tablets for CAP， can improve the clinical symptoms， has good safety.It does not increase the incidence rate of adverse reaction， has clinical application value.
[Key words] Community acquired pneumonia； Levofloxacin； Sequential； Curative effect； Symptoms； Adverse reaction
社区获得性肺炎(CAP)是常见呼吸系统常见病，为感染导致的肺部实质性感染疾病，是威胁人类健康的一种常见感染性疾病。虽然现在医疗水平不断提升，但CAP病死率并无明显下降，仍需要重视[1]。左氧氟沙星治疗CAP疗效确切[2]。本组选取我院2012年6月～2014年6月收治的164例社区获得性肺炎的患者，研究分析两种左氧氟沙星用药方案治疗CAP，为临床治疗探讨最佳用药方式。, http://www.100md.com(李秋泉?刘可权)
[关键词] 社区获得性肺炎；左氧氟沙星；序贯；疗效；症状；不良反应
[中图分类号] R563.1 [文献标识码] B [文章编号] 2095-0616(2015)06-38-03
Analysis of curative effect of two kinds of levofloxacin regimen in the treatment of community acquired pneumonia
LI Qiuquan1 LIU Kequan2 WANG Xiaoming 3
1.Department of Community Health，Nanhai Luocun Hospital of Foshan City， Foshan 528226，China；2. Department of Internal Medicine， Nanhai Luocun Hospital of Foshan City， Foshan 528226，China；3.ICU， Nanhai Luocun Hospital of Foshan City， Foshan 528226，China
[Abstract] Objective To analyze the curative effect of two kinds of levofloxacin regimen in the treatment of community acquired pneumoni(CAP). Methods 164 cases of community acquired pneumonia in our hospital from 2012 June to 2014 June were analyzed and randomly divided into the control group(82 cases)，which was given intravenous levofloxacin，and the treatment group(82 cases)which was given oral Levofloxacin Tablets on the basis of the control group after intravenous treatment.The clinical symptoms change， clinical efficacy and adverse reactions of two groups were compared with each other. Results There were statistically significant differences between the two groups in the cough， fever， pulmonary rales， leucocyte count(t=2.014，2.043，2.013， 2.001； P< 0.05)；The total clinical effective rates between the control group and the treatment group were 80.48%(66/82)， 97.56%(80/82)，the difference was statistical significance (x2=12.231，P<0.05)；The incidences of adverse reactions were 4.9% (4/82)， 9.8% (8/82)， there was significant difference between the two groups (x2=1.439，P> 0.05). Conclusion The clinical curative effect of sequential therapy of levofloxacin of injection and tablets for CAP， can improve the clinical symptoms， has good safety.It does not increase the incidence rate of adverse reaction， has clinical application value.
[Key words] Community acquired pneumonia； Levofloxacin； Sequential； Curative effect； Symptoms； Adverse reaction
社区获得性肺炎(CAP)是常见呼吸系统常见病，为感染导致的肺部实质性感染疾病，是威胁人类健康的一种常见感染性疾病。虽然现在医疗水平不断提升，但CAP病死率并无明显下降，仍需要重视[1]。左氧氟沙星治疗CAP疗效确切[2]。本组选取我院2012年6月～2014年6月收治的164例社区获得性肺炎的患者，研究分析两种左氧氟沙星用药方案治疗CAP，为临床治疗探讨最佳用药方式。, http://www.100md.com(李秋泉?刘可权)