乌司他丁用于临床防治烧伤患者早期心肌损害的效果观察(1)
[摘要]目的 探讨乌司他丁对预防烧伤患者早期心肌损害的应用价值。 方法 将2013年4月～ 2014年4月我院收治的52例烧伤患者患者随机分为观察组和对照组，观察组给予常规对症治疗+乌司他丁，对照组给予常规对症治疗，检查两组患者第2、4、6天时的血浆心肌肌钙蛋白(cTnI)含量及血浆CKMB活性变化情况，并进行统计学分析比较。 结果 对照组患者的血浆cTnI含量在伤后逐渐升高在第4天时达到峰值，第7天稍降低，但仍明显高于正常值，而观察组患者血浆cTnI含量在各时间点的含量均显著低于对照组(P<0.05)。对照组患者伤后血浆CKMB活性逐渐升高，第4天时达到峰值，第7天有所降低，但仍高于正常值，而观察组在第2、4天时的血浆CKMB活性变化程度显著低于对照组，第7天时低于正常值(P<0.01)。 结论 乌司他丁用于预防烧伤患者早期心肌损害的疗效显著，能有效降低心肌损害，值得临床推广。
[关键词]乌司他丁；烧伤；心肌损害；肌钙蛋白；肌酸激酶
[中图分类号] R644 [文献标识码] B [文章编号] 2095-0616(2015)06-47-03
Clinical observation of ulinastatin for prevention of early myocardial damage in burn patients
WANG Feng FAN Kunwu WANG Daoxin WEI Shigang
Department of Burn， Shenzhen Second People's Hospital，Shenzhen 518001，China
[Abstract] Objective To explore the application value of ulinastatin for prevention of early myocardial damage in burn patients. Methods 52 burn patients treated in our hospital from April 2013 to April 2014 were selected and randomly divided into observation group and control group. The patients in the observation group were given routine symptomatic treatment combined with ulinastatin while the patients in the control group were given routine symptomatic treatment. The content of plasma cardiac troponin (cTnI)and changes of activity of plasma CKMB in patients in two groups were checked on the second， fourth and sixth day and the statistical analysis and comparison were carried out. Results The content of plasma cardiac troponin (cTnI) and changes of activity of plasma CKMB in patients in the control group after the burn increased gradually and reached the peak on fourth day， and on the seventh day decreased slightly， but were still higher than normal value while the content of plasma cTnI in the patients in the observation group at different time points were significantly lower than those of the control group(P<0.05). The activity of plasma CKMB in patients in control group increased gradually after the burn， and reached the peak on fourth day， and on the seventh days decreased， but was still higher than the normal value. But the changes of the activity of plasma CKMB in the patients in the observation group was significantly lower than that of control group on the second and seventh day， and were lower than normal value on the seventh day (P<0.01). Conclusion The clinical effect of ulinastatin for preventive effect of early myocardial damage in burn patients is significant and can effectively reduce the myocardial damage. This method is worth the clinical promotion., http://www.100md.com(王峰?范锟铻等)
[关键词]乌司他丁；烧伤；心肌损害；肌钙蛋白；肌酸激酶
[中图分类号] R644 [文献标识码] B [文章编号] 2095-0616(2015)06-47-03
Clinical observation of ulinastatin for prevention of early myocardial damage in burn patients
WANG Feng FAN Kunwu WANG Daoxin WEI Shigang
Department of Burn， Shenzhen Second People's Hospital，Shenzhen 518001，China
[Abstract] Objective To explore the application value of ulinastatin for prevention of early myocardial damage in burn patients. Methods 52 burn patients treated in our hospital from April 2013 to April 2014 were selected and randomly divided into observation group and control group. The patients in the observation group were given routine symptomatic treatment combined with ulinastatin while the patients in the control group were given routine symptomatic treatment. The content of plasma cardiac troponin (cTnI)and changes of activity of plasma CKMB in patients in two groups were checked on the second， fourth and sixth day and the statistical analysis and comparison were carried out. Results The content of plasma cardiac troponin (cTnI) and changes of activity of plasma CKMB in patients in the control group after the burn increased gradually and reached the peak on fourth day， and on the seventh day decreased slightly， but were still higher than normal value while the content of plasma cTnI in the patients in the observation group at different time points were significantly lower than those of the control group(P<0.05). The activity of plasma CKMB in patients in control group increased gradually after the burn， and reached the peak on fourth day， and on the seventh days decreased， but was still higher than the normal value. But the changes of the activity of plasma CKMB in the patients in the observation group was significantly lower than that of control group on the second and seventh day， and were lower than normal value on the seventh day (P<0.01). Conclusion The clinical effect of ulinastatin for preventive effect of early myocardial damage in burn patients is significant and can effectively reduce the myocardial damage. This method is worth the clinical promotion., http://www.100md.com(王峰?范锟铻等)