大剂量谷维素联合β—受体阻滞剂治疗心血管神经症的疗效(1)
[摘要] 目的 对大剂量谷维素联合β-受体阻滞剂治疗心血管神经症的疗效进行研究与探讨。 方法 对在我院就诊的112例患有心血管神经症的患者利用不同治疗方式进行分组对照研究。观察组患者运用大剂量谷维素联合β-受体阻滞剂治疗；对照组患者运用常规治疗，在持续治疗2周后对患者进行随访，调查具体疗效。 结果 观察组和对照组各周汉密尔顿抑郁评分、汉密尔顿焦虑评分以及心血管神经症评分与治疗前相比均有明显下降。治疗各周后两组的汉密尔顿抑郁评分和汉密尔顿焦虑评分比较，差异具有统计学意义(P<0.05)。 结论 大剂量谷维素联合β-受体阻滞剂对于心血管神经症患者有良好与确切的治疗效果，此方式值得在临床上广泛推广。
[关键词] 大剂量谷维素；β-受体阻滞剂；联合用药；心血管神经症；临床疗效分析
[中图分类号] R54；R749.7 [文献标识码] A [文章编号] 2095-0616(2017)10-25-03
Curative effect of high-dose oryzanol combined with β-blocker in treatment of cardiovascular neurosis
WEI Wenqi ZHENG Zhifei MO Xiaoxiong
Zhanjiang Central Hospital，Zhanjiang 524200，China
[Abstract] Objective To research and explore curative effect of high-dose oryzanol combined with β-blocker in treatment of cardiovascular neurosis. Methods 112 patient with cardiovascular neurosis who were treated in our hospital were given grouping controlled study according to different treatment methods.Patients in the observation group were treated by high-dose oryzanol combined with β-blocker while patients in the observation group were given routine treatment.After continued treatment for 2 weeks，patients were given follow-up and specific curative effects were researched. Results Hamilton Depression Scale (HAMD)，Hamilton Anxiety Rating Scale (HAMA) and score of cardiovascular neurosis of every week in the observation group and the control group were significantly decreased compared with those before treatment.Differences in HAMD score and HAMA score after treatment of every week had statistical significance (P<0.05). Conclusion High-dose oryzanol combined with β-blocker in treatment of patients with cardiovascular neurosis has good and acute curative effect，which is worthy of widely clinical promotion.
[Key words] High-dose oryzanol；β-blocker；Combined medication；Cardiovascular neurosis；Analysis on clinical curative effect
心血管神經症是一种以心血管类疾病为主要的临床表现的疾病群[1-2]。这种病症是一种功能性的神经症，病症临床方面的表现尤其特殊，患者一般会有心血管方面或者呼吸系统方面疾病的临床表现，经临床具体检查后未发现病变，但患者的不适感非常明显，此种状况下症状被称作心血管神经症。现在临床上对于心血管神经症的治疗手段大多为谷维素药物治疗辅助心理治疗[3]。谷维素对内分泌调节有明显的促进作用，并且能明显改善患者的自主神经功能；β-受体阻滞剂能明显抑制患者体内肾上腺素能受体，可将患者心肌收缩力减弱、减少心肌耗氧量以及降低血压，从而达到将儿茶酚胺对心脏的损害程度降低的目的，以改善患者心血管功能[4-6]。为对大剂量谷维素联合β-受体阻滞剂治疗心血管神经症的疗效进行分析与探讨，现选取我院自2015年9月～2016年12月收治的112例确诊为心血管神经症患者，对患者的临床资料进行回顾性分析，现报道如下。
1 资料与方法
1.1 一般资料
选取我院自2015年9月～2016年12月收治的112例确诊为心血管神经症患者，所有患者都存在：(1)心悸、胸闷、胸痛、失眠、多梦、呼吸困难、四肢发冷、头晕与食欲不振等临床症状；(2)患者肝肾
功能正常，未见甲状腺功能亢进；(3)汉密尔顿抑郁量表自评分≥17分，并且汉密尔顿焦虑自评分≥14分。所有患者随机分为对照组与观察组，各56例，对照组中男19例，女37例，年龄26～58岁，平均(41.6±10.3)岁；观察组男20例，女36例，年龄27～57岁，平均(40.1±8.9)岁。两组患者在性别、年龄等一般资料比较，差异无统计学意义(P>0.05)，具有可比性。 (魏文琦?郑智非?莫小雄)
[关键词] 大剂量谷维素；β-受体阻滞剂；联合用药；心血管神经症；临床疗效分析
[中图分类号] R54；R749.7 [文献标识码] A [文章编号] 2095-0616(2017)10-25-03
Curative effect of high-dose oryzanol combined with β-blocker in treatment of cardiovascular neurosis
WEI Wenqi ZHENG Zhifei MO Xiaoxiong
Zhanjiang Central Hospital，Zhanjiang 524200，China
[Abstract] Objective To research and explore curative effect of high-dose oryzanol combined with β-blocker in treatment of cardiovascular neurosis. Methods 112 patient with cardiovascular neurosis who were treated in our hospital were given grouping controlled study according to different treatment methods.Patients in the observation group were treated by high-dose oryzanol combined with β-blocker while patients in the observation group were given routine treatment.After continued treatment for 2 weeks，patients were given follow-up and specific curative effects were researched. Results Hamilton Depression Scale (HAMD)，Hamilton Anxiety Rating Scale (HAMA) and score of cardiovascular neurosis of every week in the observation group and the control group were significantly decreased compared with those before treatment.Differences in HAMD score and HAMA score after treatment of every week had statistical significance (P<0.05). Conclusion High-dose oryzanol combined with β-blocker in treatment of patients with cardiovascular neurosis has good and acute curative effect，which is worthy of widely clinical promotion.
[Key words] High-dose oryzanol；β-blocker；Combined medication；Cardiovascular neurosis；Analysis on clinical curative effect
心血管神經症是一种以心血管类疾病为主要的临床表现的疾病群[1-2]。这种病症是一种功能性的神经症，病症临床方面的表现尤其特殊，患者一般会有心血管方面或者呼吸系统方面疾病的临床表现，经临床具体检查后未发现病变，但患者的不适感非常明显，此种状况下症状被称作心血管神经症。现在临床上对于心血管神经症的治疗手段大多为谷维素药物治疗辅助心理治疗[3]。谷维素对内分泌调节有明显的促进作用，并且能明显改善患者的自主神经功能；β-受体阻滞剂能明显抑制患者体内肾上腺素能受体，可将患者心肌收缩力减弱、减少心肌耗氧量以及降低血压，从而达到将儿茶酚胺对心脏的损害程度降低的目的，以改善患者心血管功能[4-6]。为对大剂量谷维素联合β-受体阻滞剂治疗心血管神经症的疗效进行分析与探讨，现选取我院自2015年9月～2016年12月收治的112例确诊为心血管神经症患者，对患者的临床资料进行回顾性分析，现报道如下。
1 资料与方法
1.1 一般资料
选取我院自2015年9月～2016年12月收治的112例确诊为心血管神经症患者，所有患者都存在：(1)心悸、胸闷、胸痛、失眠、多梦、呼吸困难、四肢发冷、头晕与食欲不振等临床症状；(2)患者肝肾
功能正常，未见甲状腺功能亢进；(3)汉密尔顿抑郁量表自评分≥17分，并且汉密尔顿焦虑自评分≥14分。所有患者随机分为对照组与观察组，各56例，对照组中男19例，女37例，年龄26～58岁，平均(41.6±10.3)岁；观察组男20例，女36例，年龄27～57岁，平均(40.1±8.9)岁。两组患者在性别、年龄等一般资料比较，差异无统计学意义(P>0.05)，具有可比性。 (魏文琦?郑智非?莫小雄)