不同孕周孕妇及新生儿EB病毒感染及妊娠结局观察(1)

http://www.100md.com 2017年10月8日 《中国医药科学》 2017年第14期

     [摘要]目的 观察不同孕周孕妇及其新生儿EB病毒感染发生情况及EB病毒孕妇妊娠结局。方法 回顾性分析2016年1月～2017年3月间在本院接受常规孕检并最终在本院分娩186例孕妇，对比不同孕周孕妇EB感染发生率及母婴传播率，观察EB感染对于孕妇妊娠结局的影响，不同分娩方式新生儿EB感染发生率，观察并对比EB感染对于新生儿结局的影响。结果 <12周孕妇中EB感染率为2.69%，12～28周孕妇中EB感染率为8.60%，>28周孕妇中EB感染率为17.74%，不同孕周孕婦EB感染率具有统计学意义(P<0.05)；不同孕周EB感染孕妇的母婴垂直传染率无统计学意义(P>0.05)。EB病毒感染孕妇与未感染孕妇中的妊娠意外终止率、围产期危重症率及顺产率均未见明显差异(P>0.05)。EB病毒感染产妇顺产新生儿EB感染率为75.00%，剖宫产新生儿EB感染率为53.85%(P>0.05)。EB病毒感染新生儿中不良结局发生率高于未感染EB病毒的新生儿(P<0.05)。结论 EB病毒感染的发生率可随妊娠时间的延长而上升，因此妊娠晚期应特别注意预防EB病毒感染；母婴间可发生EB病毒垂直传播，新生儿EB病毒感染可直接导致新生儿不良结局；剖宫产对于降低新生儿EB病毒感染无明显作用；因此预防孕妇EB病毒感染对于预防新生儿EB病毒感染、提高新生儿质量均具有基础作用。

    [关键词] 不同孕周；EB病毒；母婴垂直传播；新生儿；新生儿质量

    [中图分类号] R714 [文献标识码] A [文章编号] 2095-0616(2017)14-62-04

    Observation of EB infection and pregnancy outcome in pregnant women and neonates of different gestational age

    TUO Min

    Department of Obstetrics and Gynecology， Huizhou Third People’s Hospital， Huizhou 516001， China

    [Abstract] Objective To observe the occurrence of maternal and eb-virus infection in pregnant women during pregnancy and the outcome of pregnancy. Methods 186 cases of pregnant women in our hospital for routine physical checks and delivery from January 2016 to March 2017 were retrospectively analyzed. Different gestational weeks pregnant women EB infection incidence and mother-to-child transmission rate were compared. The effects of EB infection in pregnant women prospective pregnancy， the different ways childbirth neonatal EB infection were observed. The effects Of EB infection on neonatal outcome were observed and compared. Results The EB infection rate of <12 weeks pregnant women was 2.69%， the EB infection rateof 12-28 weeks pregnant women was 8.60%， the EB infection rateof >28 weeks pregnant women was 17.74 %， and EB infection rate among pregnant women in different gestational age was statistically significant， P<0.05. The rate of maternal and infant transmission of maternal and infan in pregnant women was not statistically significant， P>0.05. There was no significant difference in the incidence of pregnancy abnormal rates， perinatal risk， and the rate of vaginal delivery in pregnant women and non-infected pregnant women， P>0.05. The EB infection rate of EB infected women was 75%， the rate of EB infection in cesarean section was 53.85%， P>0.05. The incidence of adverse outcomes in EB infected neonates was higher than that in neonates who are not infected with EB， P<0.05. Conclusion The incidence of EB infection increases with the duration of pregnancy. Therefore， special attention should be paid to prevent EB virus infection in late pregnancy. Vertical transmission of EB virus might occur between mother and infant， neonatal EB virus infection might directly lead to neonatal adverse outcomes. Cesarean section has no significant effect on reducing neonatal EB virus infection. Therefore， prevention of EB infection in pregnant women has a basic role in preventing neonatal EB virus infection and improving neonatal quality.(庹闽)

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