黄云 潘程宇 田耀洲 李慧

    [摘要]功能性便秘(FC)是一种功能性胃肠病，近年来研究发现 FC 发病率越来越高，且多伴有焦虑抑郁的心理障碍。本文简述了西医对伴有焦虑抑郁状态的 FC 的发病机制的研究进展，可能与结肠内5-羟色胺(5-HT)水平、肠道菌群变化及短链脂肪酸和胆汁酸含量改变相关，但目前西医多采用泻剂联合抗焦虑抑郁药物治疗，无较好的治疗手段，存在停药易反复的缺点。同时，本文从中医角度详述了七种不同证型便秘的病因病机、辨证论治及中医外治法的研究进展，为临床上治疗伴有焦虑抑郁状态的 FC 总结研究思路和方法。

    [关键词]功能性便秘;焦虑抑郁;中医药;治疗进展

    [中图分类号] R256.35; R-1? [文献标识码] A? [文章编号]2095-0616(2021)24-0048-05

    Progress in treatment of functional constipation with traditional chinese medicine accompanied by anxiety and depression

    HUANG? Yun1? PAN? Chengyu2? TIAN? Yaozhou2? LI? Hui2

    1.The Third Clinical Medical Academy， Nanjing University of Chinese Medicine， Jiangsu， Nanjing 210028， China;2.Jiangsu Province Academy ofTraditional Chinese Medicine， Jiangsu， Nanjing 210028， China

    [Abstract] Functional constipation(FC) is a functional gastroenteropathy. In recent years， studies have found that the incidence of FC is increasing， and it is mostly accompanied by psychological disorders of anxiety and depression. This article briefly reviews the research progress in the pathogenesis of FC with anxiety and depression in western medicine ......