邢维昊 张婕 巫晓宇 刘凤 熊静

    [摘要]证据表明，脑源性神经营养因子前体(proBDNF)和成熟脑源性神经营养因子(mBDNF)通过维持神经元存活、可塑性和调节神经递质，在阿尔茨海默病(AD)、帕金森病(PD)等神经退行性疾病的病理生理机制中发挥重要作用。慢性炎症反应是神经退行性疾病的关键性驱动因素，影响多个脑源性神经营养因子(BDNF)相关的信号通路。现对proBDNF、mBDNF和神经炎症在神经退行性疾病中的作用机制及研究进展进行综述，了解神经炎症与 BDNF 在神经退行性疾病的相互作用，有助于制订新的治疗策略。

    [关键词]脑源性神经营养因子;神经炎症;神经退行性疾病;阿尔茨海默病;帕金森病

    [中图分类号] R-1;R741[文献标识码] A [文章编号]2095-0616(2022)10-0021-04

    Progress in research on the role of brain-derived neurotrophic factor and neuroinflammation in neurodegenerative diseases

    XINGWeihaoZHANGJieWUXiaoyuLIUFengXIONGJing

    Department of Neurology， the Second Affiliated Hospital of Kunming Medical University， Yunnan， Kunming 650101，China

    [Abstract] There is considerable evidence that pro-brain-derived neurotrophic factor (proBDNF) and mature brain-derived neurotrophic factor (mBDNF) play important roles in the pathophysiology of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) by regulating neurotransmitters， and maintaining neuronal survival and plasticity. Chronic inflammatory response is a key driver of neurodegenerative diseases ......