潘啸天 贾瀛娴 兰义兵 王黎 周坚红

    [摘要]异常子宫出血(AUB)是妇科常见的症状。根据2011年国际妇产科联盟(FIGO)发表的“PALM- COEIN”病因分类系统，子宫肌瘤(leiomyoma)引起的异常子宫出血(AUB-L)为最常见的结构性病因。目前 AUB-L 的发病机制尚不明确，本文就现有相关报道对其发病机制进行综述。AUB-L 的发病机制具有复杂的多因素特点，主要包括肌瘤本身及子宫内膜微环境的改变。其中，机体可能通过改变性激素及其受体的表达，调控细胞因子，引起微环境的改变，从而引起子宫内膜形态和功能改变，最终导致疾病发生。

    [关键词]异常子宫出血;子宫肌瘤;月经量过多;性激素受体

    [中图分类号] R711.52[文献标识码] A [文章编号]2095-0616(2022)10-0030-04

    Thepathogenesisof abnormaluterinebleedingcausedby leiomyoma

    PANXiaotianJIAYingxianLANYibingWANGLiZHOUJianhong

    Department of Gynecology， Women's Hospital， School of Medicine， Zhejiang University，Zhejiang，Hangzhou 310006，China

    [Abstract] Abnormal uterine bleeding (AUB) is one of the common symptoms in gynecology. According to the "PALM-COEIN" etiological classification system published by the International Federation of Gynecology and Obstetrics (FIGO) in 2011， abnormal uterine bleeding caused by leiomyoma (AUB-L) is the most common one among structural causes. However， the pathogenesis of AUB-L is still unclear. In this article， we reviewed the existing related reports on its pathogenesis. The pathogenesis of AUB-L is characterized by complex and multi- factors ......