筋骨痛宁胶囊联合塞来昔布治疗创伤性髋关节滑膜炎临床观察(1)
【摘 要】目的：觀察筋骨痛宁胶囊联合塞来昔布治疗创伤性髋关节滑膜炎的临床疗效。方法：将75例创伤性髋关节滑膜炎患者随机分为治疗组、对照1组、对照2组，每组25例。治疗组给予筋骨痛宁胶囊联合塞来昔布胶囊口服治疗，对照1组单独给予塞来昔布胶囊口服治疗，对照2组单独给予筋骨痛宁胶囊口服治疗。所有患者患肢均辅以髋部微波理疗及持续皮牵引制动，嘱患者严格卧床休息，连续治疗
3周，随访3个月。观察3组临床疗效，治疗前后视觉模拟评分法(VAS)评分、Barthel指数、红细胞沉降率(ESR)、C-反应蛋白(CRP)，以及不良反应、3个月后复发情况。结果：治疗组临床治愈18例，显效5例，好转2例，无效0例，总有效率为100.00%；对照1组临床治愈10例，显效6例，好转4例，无效5例，总有效率为80.00%；对照2组临床治愈10例，显效4例，好转4例，无效7例，总有效率为72.00%。治疗组与对照1组、对照2组比较，差异有统计学意义(P < 0.05)。治疗后，3组Barthel指数、VAS评分、ESR及CRP较治疗前均有明显改善(P < 0.05)，且治疗组优于对照1组、对照2组(P < 0.05 )。
所有患者在治疗过程中未出现明显不良反应。治疗后3个月，治疗组无复发病例，对照1组复发2例，对照2组复发3例。结论：筋骨痛宁胶囊联合塞来昔布治疗创伤性髋关节滑膜炎，安全有效，且不易复发，值得临床应用和推广。
【关键词】 髋关节滑膜炎；创伤性；筋骨痛宁胶囊；塞来昔布
【ABSTRACT】Objective：To observe the clinical effect of Jingu Tongning Jiaonang(筋骨痛宁胶囊)combined with celecoxib in the treatment of traumatic synovitis of hip joint.Methods：Seventy five patients with traumatic synovitis of hip joint were randomly divided into a treatment group，control group 1，and control group 2，25 cases in each group.The treatment group was treated with Jingu Tongning Jiaonang combining celecoxib；control group 1 was required to take celecoxib capsules orally，and control group 2 was required to take Jingu Tongning Jiaonang orally.Patients in all groups were given hip microwave physiotherapy and skin traction for 3 weeks staying in bed and followed up for 3 months，observing their clinical efficacy，visual analogue scale(VAS)score，Barthel index，erythrocyte sedimentation rate(ESR)and C-reactive protein(CRP)before and after treatment，adverse reactions，and recurrence after 3 months.Results：In the treatment group，18 cases were cured，5 cases were markedly effective，2 cases were mproved，and no case was ineffective，the total efficiency being 100.00%；in control group 1，10 cases were cured，6 cases were markedly effective，4 cases were improved，5 cases
were ineffective，and the total efficiency was 80.00%；and in control group 2，10 cases were cured，4 cases were markedly effective，4 cases were improved，7 cases were ineffective，and the total effective rate was 72.00%.The difference between the treatment group and the other two control groups was statistically significant(P < 0.05).After treatment，the Barthel index，VAS score，ESR and CRP of the three groups were significantly improved compared with those before treatment(P < 0.05)，and the treatment group was better than control group 1 and 2(P < 0.05).No obvious adverse reactions were observed in all patients during the treatment.Three months after treatment，no recurrence was in the treatment group，two cases of recurrence were in control group 1，and three cases recured in control group 2. (刘怀省 韩文朝 白宗堂 乔登朝)
3周，随访3个月。观察3组临床疗效，治疗前后视觉模拟评分法(VAS)评分、Barthel指数、红细胞沉降率(ESR)、C-反应蛋白(CRP)，以及不良反应、3个月后复发情况。结果：治疗组临床治愈18例，显效5例，好转2例，无效0例，总有效率为100.00%；对照1组临床治愈10例，显效6例，好转4例，无效5例，总有效率为80.00%；对照2组临床治愈10例，显效4例，好转4例，无效7例，总有效率为72.00%。治疗组与对照1组、对照2组比较，差异有统计学意义(P < 0.05)。治疗后，3组Barthel指数、VAS评分、ESR及CRP较治疗前均有明显改善(P < 0.05)，且治疗组优于对照1组、对照2组(P < 0.05 )。
所有患者在治疗过程中未出现明显不良反应。治疗后3个月，治疗组无复发病例，对照1组复发2例，对照2组复发3例。结论：筋骨痛宁胶囊联合塞来昔布治疗创伤性髋关节滑膜炎，安全有效，且不易复发，值得临床应用和推广。
【关键词】 髋关节滑膜炎；创伤性；筋骨痛宁胶囊；塞来昔布
【ABSTRACT】Objective：To observe the clinical effect of Jingu Tongning Jiaonang(筋骨痛宁胶囊)combined with celecoxib in the treatment of traumatic synovitis of hip joint.Methods：Seventy five patients with traumatic synovitis of hip joint were randomly divided into a treatment group，control group 1，and control group 2，25 cases in each group.The treatment group was treated with Jingu Tongning Jiaonang combining celecoxib；control group 1 was required to take celecoxib capsules orally，and control group 2 was required to take Jingu Tongning Jiaonang orally.Patients in all groups were given hip microwave physiotherapy and skin traction for 3 weeks staying in bed and followed up for 3 months，observing their clinical efficacy，visual analogue scale(VAS)score，Barthel index，erythrocyte sedimentation rate(ESR)and C-reactive protein(CRP)before and after treatment，adverse reactions，and recurrence after 3 months.Results：In the treatment group，18 cases were cured，5 cases were markedly effective，2 cases were mproved，and no case was ineffective，the total efficiency being 100.00%；in control group 1，10 cases were cured，6 cases were markedly effective，4 cases were improved，5 cases
were ineffective，and the total efficiency was 80.00%；and in control group 2，10 cases were cured，4 cases were markedly effective，4 cases were improved，7 cases were ineffective，and the total effective rate was 72.00%.The difference between the treatment group and the other two control groups was statistically significant(P < 0.05).After treatment，the Barthel index，VAS score，ESR and CRP of the three groups were significantly improved compared with those before treatment(P < 0.05)，and the treatment group was better than control group 1 and 2(P < 0.05).No obvious adverse reactions were observed in all patients during the treatment.Three months after treatment，no recurrence was in the treatment group，two cases of recurrence were in control group 1，and three cases recured in control group 2. (刘怀省 韩文朝 白宗堂 乔登朝)