黄璐 谭旭仪 邝高艳 卢敏

    【摘 要】目的：观察加味独活寄生合剂对兔膝骨关节炎显微结构的影响。方法：采用随机数字表法将80只白兔分为正常对照组、模型对照组、阳性对照组和独活寄生组，每组20只。除正常对照组外，其余组均成功制备KOA模型。独活寄生组给予加味独活寄生合剂6.8 mL·kg^-1·d^-1灌胃，阳性对照组给予盐酸氨基葡萄糖胶囊0.07 g·kg^-1·d^-1灌胃，正常对照组和模型对照组给予等剂量生理盐水灌胃。在实验干预前、干预第2，4，8周时，对关节软骨形态及显微结构进行观察，并采用番红固绿染色进行Mankins关节软骨评分。结果：与模型对照组比较，独活寄生组膝关节大体观察得到有效改善。模型对照组、阳性对照组、独活寄生组Mankins软骨评分在干预前和干预第2，4，8周均高于正常对照组，且阳性对照组、独活寄生组Mankins软骨评分在干预第2，4，8周均低于模型对照组，差异有统计学意义(P -1·d^-1of Jiawei Duhuo Jisheng Heji by gavage，the positive control group was given 0.07 g·kg^-1·d^-1of glucosamine hydrochloride capsule by gavage，and the normal control group and model control group were given the same dose of normal saline by gavage.The morphology and microstructure of articular cartilage were observed before the experimental intervention and at the 2nd ......