【摘 要】目的：通过运用涎腺超声技术评估补肾润燥方治疗肝肾阴虚型原发性干燥综合征累及涎腺的临床疗效，进而探索涎腺超声技术评估中医药治疗原发性干燥综合征疗效的作用。方法：将78例原发性干燥综合征患者随机分为治疗组和对照组，每组39例。对照组服用硫酸羟氯喹，治疗组在此基础上加用补肾润燥方。2组疗程均为12周。观察2组治疗前后ESSDAI评分、中医证候积分、超声半定量分级、剪切波弹性模量。结果：2组各脱落1例，最终每组纳入38例。治疗后，2组ESSDAI评分较治疗前下降(P < 0.05)；且治疗组下降程度优于对照组(P < 0.05)。治疗组临床痊愈0例，显效10例，有效25例，无效3例，总有效率为92.10%；对照组临床痊愈0例，显效3例，有效25例，无效10例，总有效率为73.68%。2组比较，差异有统计学意义(P < 0.05)。治疗后，2组涎腺超声半定量分级均有所改善，治疗组改善率为73.68%，对照组改善率为47.37%(P < 0.05)；2组4个腺体的剪切波弹性模量较治疗前均下降(P < 0.05)，且治疗组下降程度优于对照组(P < 0.05)。结论：补肾润燥方对肝肾阴虚型原发性干燥综合征累及涎腺的患者疗效确切，涎腺超声可以协助评估中医药治疗原发性干燥综合征疗效。

    【关键词】 原发性干燥综合征；涎腺超声；补肾润燥方；临床观察

    Evaluation of the Therapeutic Effect of Bushen Runzao Fang(补肾润燥方)on Primary Sj?gren's SyndromeBased on Salivary Gland UltrasoundLU Dong-qing，WU Fan，PAN Xin

    【ABSTRACT】Objective：To evaluate the clinical efficacy of Bushen Runzao Fang(补肾润燥方)9g9lAYq0Srg9Ku+XMZcmfdoDwrfbvB3uA/wX2MSszCI=in treating primary Sj?gren's syndrome with liver kidney yin deficiency involving the salivary glands using salivary gland ultrasound technology，and to explore the role of salivary gland ultrasound technology in evaluating the efficacy of traditional Chinese medicine in treating primary Sj?gren's syndrome.Methods：Seventy-eight patients with primary Sj?gren's syndrome were randomly divided into a treatment group and a control group ......