【摘要】目的 观察托伐普坦和大剂量呋塞米治疗顽固性心力衰竭的临床疗效对比。方法 选取我院2014年12月～2017年12月收治的因顽固性心力衰竭住院的48例患者(女20例，男28例)，随机分成两组，第一组给以常规药物加托伐普坦，第二组予常规药物加大剂量呋塞米，共治疗5～6天，观察患者心功能，心超，BNP和水钠潴留的体征变化。结果 和呋塞米组相比，托伐普坦组治疗后患者心功能好转，水钠潴留明显减轻。结论 和大剂量呋塞米治疗方法相比，托伐普坦治疗顽固性心力衰竭疗效确切。

    【关键词】呋塞米；托伐普坦；心力衰竭；利尿剂抵抗

    【中图分类号】R541 【文献标识码】A 【文章编号】ISSN.2095-6681.2018.25..02

    【Abstract】Objective To compare the clinical effects of tolvaptan and high-dose furosemide in the treatment of refractory heart failure.Methods Forty-eight patients (20 females and 28 males) with refractory heart failure hospitalized in our hospital from December 2014 to December 2017 were randomly divided into two groups. The first group was treated with routine drugs plus tovaptan ......