Orexin系统在睡眠剥夺影响学习记忆中的作用研究进展(3)
[15]Chen L，McKenna JT，Bolortuya Y，et al.Knockdown of orexin type 1 receptor in rat locus coeruleusincreases REM sleep during the dark period[J].Eur J Neurosci，2010，32(9)：1528-1536.
[16]Chen L，McKenna JT，Bolortuya Y，et al.Knockdown of orexin type 2 receptor in the lateral pontomesencephalic tegmentum of rats increases REM sleep[J].Eur J Neurosci，2013，37(6)：957-963.
[17]Yoshida Y，Fujiki N，Nakajima T，et al.Fluctuation of extracellular hypocretin-1 (orexin A)levels in the rat in relation to the light-dark cycle and sleep-wake activities[J].Eur J Neurosci，2001，14(7)：1075-1081.
, http://www.100md.com
[18]Estabrooke I，McCarthy MT，Ko E，et al.Fos expression in orexin neurons varies with behavioral state[J].Neurosci，2001，21(5)：1656-1662.
[19]Arthaud S，Varin C，Gay N，et al.Paradoxical(REM)sleep deprivation in mice u-sing the small-platforms-over-water method：Polysomnographic analyses and Melanin concentrating hormone and Hypocretin/orexin neuronal activation before，during and after deprivation[J].J Sleep Res，2015，24(3)：309-319.
, 百拇医药 [20]Jaeger LB，Farr SA，Banks WA，Morley JE.Effects of orexin-A on memory proc-essing[J].Peptides，2002，23(9)：1683-1688.
[21]Roh JH，Jiang H，Finn MB，et al.Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer′s disease[J].J Exp Med.2014，211(13)：2487-2496.
[22]Zhao X，Zhang RX，Tang S，et al.Orexin-A-induced ERK1/2 activation reverses impaired spatial learning andmemory in pentylenetetrazol kndled rats via OX1R-mediated hippocampal neurogenesis[J].Peptides，2014，54：140-147.
, http://www.100md.com
[23]Raoof R，Esmaeili-Mahani S，Abbasnejad M，et al.Changes in hippocampal ore-xin 1 receptor expression involved intooth pain-induced learning and memory impairment in rats[J].Neuropeptides，2015，50：9-16.
[24]Song J，Kim E，Kim CH，et al.The role of orexin in post-stroke inflammation，cognitive decline，and depression[J].Mol Brain，2015，11：8-16.
[25]Akbari E，Motamedi F，Davoodi FG，et al.Orexin-1 receptor mediates long-term potentiation in the dentate gyrus area offreely moving rats[J].Behav Brain Res，2011，216(1)：375-380
, 百拇医药
[26]Tang J，Chen J，Ramanjaneya M，et al.The signalling profile of recombinant hu-man orexin-2 receptor[J].Cell Signal，2008，20(9)：1651-1661.
[27]Aleisa AM，Helal G，Alhaider IA，et al.Acute nicotinetreatment prevents REM sleep deprivation-induced learningand memory impairment in rat[J].Hippocampus，2011，21(8)：899-909.
[28]Moreira KM，Ferreira TL，Hipolide DC，et al.Modafinil prevents inhibitory avoi-dance memory deficit induced by sleep deprivation in rats[J].Sleep，2010，33(7)：990-993.
[29]Alhaider IA，Alkadhi KA.Caffeine treatment prevents rapid eye movement sleep deprivation-induced impairment of late-phase long-termpotentiation in the dentate Gyrus[J].Eur J Neurosci，2015，42(10)：2843-2850., http://www.100md.com(倪丽艳 唐吉友)
[16]Chen L，McKenna JT，Bolortuya Y，et al.Knockdown of orexin type 2 receptor in the lateral pontomesencephalic tegmentum of rats increases REM sleep[J].Eur J Neurosci，2013，37(6)：957-963.
[17]Yoshida Y，Fujiki N，Nakajima T，et al.Fluctuation of extracellular hypocretin-1 (orexin A)levels in the rat in relation to the light-dark cycle and sleep-wake activities[J].Eur J Neurosci，2001，14(7)：1075-1081.
, http://www.100md.com
[18]Estabrooke I，McCarthy MT，Ko E，et al.Fos expression in orexin neurons varies with behavioral state[J].Neurosci，2001，21(5)：1656-1662.
[19]Arthaud S，Varin C，Gay N，et al.Paradoxical(REM)sleep deprivation in mice u-sing the small-platforms-over-water method：Polysomnographic analyses and Melanin concentrating hormone and Hypocretin/orexin neuronal activation before，during and after deprivation[J].J Sleep Res，2015，24(3)：309-319.
, 百拇医药 [20]Jaeger LB，Farr SA，Banks WA，Morley JE.Effects of orexin-A on memory proc-essing[J].Peptides，2002，23(9)：1683-1688.
[21]Roh JH，Jiang H，Finn MB，et al.Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer′s disease[J].J Exp Med.2014，211(13)：2487-2496.
[22]Zhao X，Zhang RX，Tang S，et al.Orexin-A-induced ERK1/2 activation reverses impaired spatial learning andmemory in pentylenetetrazol kndled rats via OX1R-mediated hippocampal neurogenesis[J].Peptides，2014，54：140-147.
, http://www.100md.com
[23]Raoof R，Esmaeili-Mahani S，Abbasnejad M，et al.Changes in hippocampal ore-xin 1 receptor expression involved intooth pain-induced learning and memory impairment in rats[J].Neuropeptides，2015，50：9-16.
[24]Song J，Kim E，Kim CH，et al.The role of orexin in post-stroke inflammation，cognitive decline，and depression[J].Mol Brain，2015，11：8-16.
[25]Akbari E，Motamedi F，Davoodi FG，et al.Orexin-1 receptor mediates long-term potentiation in the dentate gyrus area offreely moving rats[J].Behav Brain Res，2011，216(1)：375-380
, 百拇医药
[26]Tang J，Chen J，Ramanjaneya M，et al.The signalling profile of recombinant hu-man orexin-2 receptor[J].Cell Signal，2008，20(9)：1651-1661.
[27]Aleisa AM，Helal G，Alhaider IA，et al.Acute nicotinetreatment prevents REM sleep deprivation-induced learningand memory impairment in rat[J].Hippocampus，2011，21(8)：899-909.
[28]Moreira KM，Ferreira TL，Hipolide DC，et al.Modafinil prevents inhibitory avoi-dance memory deficit induced by sleep deprivation in rats[J].Sleep，2010，33(7)：990-993.
[29]Alhaider IA，Alkadhi KA.Caffeine treatment prevents rapid eye movement sleep deprivation-induced impairment of late-phase long-termpotentiation in the dentate Gyrus[J].Eur J Neurosci，2015，42(10)：2843-2850., http://www.100md.com(倪丽艳 唐吉友)