二联用药联合睡眠干预对社区高血压患者血压控制率及睡眠质量的影响研究(1)
摘要 目的：探讨二联用药联合睡眠干预在社区高血压患者临床治疗中的应用价值。方法：选取2017年1月至2018年5月昌平城区社区卫生服务中心收治的高血压患者60例作为研究对象，随机分为对照组和观察组，每组30例，对照组单用非洛地平治疗，观察组应用美托洛尔联合非洛地平治疗二联用药治疗，并对患者的睡眠质量进行干预和监测，观察2组临床疗效和治疗前后患者睡眠质量。结果：治疗2个月后，观察组患者收缩压、舒张压指标水平均较治疗前及观察组治疗后下降;观察组患者治疗期间不良反应发生率显著低于对照组的发生率;观察组患者睡眠质量优于对照组，差异有统计学意义(P<0.05)。结论：针对社区高血压疾病，联合应用美托洛尔+非洛地平治疗，并同步实施睡眠监测干预可获得良好降压效果，同时改善患者睡眠质量，且可降低药物不良反应，值得推广。
关键词 美托洛尔;非洛地平;社区高血压;睡眠质量
Abstract Objective：To explore the clinical application value of two-drug combined with sleep intervention in community hypertension patients.Methods：Will be in January 2017 to May 2018 of 60 patients admitted in the community hypertension patients randomly divided into observation group(30 cases)and control group(30 cases)and control group，with felodipine treatment，observation group application of metoprolol combined felodipine duplex treatment drug treatment，and the sleep quality of patients with intervention and monitoring，observing two groups of patients before and after the clinical curative effect and treatment of sleep quality.Results：After 2 months of treatment，the systolic blood pressure and diastolic blood pressure in the observation group were lower than those before and after treatment.The incidence of adverse reactions during treatment was significantly lower in the observation group than in the control group.The quality of sleep in the observation group was better than that in the control group，and the difference was statistically significant(P<0.05).Conclusion：For hypertension in the community，combined application of metoprolol+felodipine therapy and synchronous implementation of sleep monitoring intervention can achieve good antihypertensive effect，improve patients′ sleep quality at the same time，and reduce adverse drug reactions，which is worthy of promotion.
Key Words Metoprolol;Felodipine;Community hypertension;Quality of sleep
中图分类号：R544.1;R338.63文献标识码：Adoi：10.3969/j.issn.2095-7130.2019.04.007
高血压是临床中常见的慢性疾病，此类患者大多分布在社区[1]。高血压患者的临床症状主要表现为血压处在正常水平以上，血压持续处在高水平状态可引起心脑血管疾病，这严重影响患者的生命质量及生命健康[2]。针对社区高血压，疾病的治疗上主要是通过合理用药将患者的血压稳定在正常水平，降低各种并发症的发生率，同时还需减少血压波动及反弹。高血压引起的应激反应等症状对患者心理状态影响明显，干扰正常睡眠，治疗高血压的同时，同步对合并睡眠障碍的患者进行睡眠干预可有效提高疗效，改善患者睡眠质量，提高血压控制率。本研究中，应用美托洛尔联合非洛地平治疗社区高血压并同时对患者进行睡眠干预，效果显著，详细报道如下。
1 资料与方法
1.1 一般资料 选取2017年1月至2018年5月昌平城区社区卫生服务中心收治的高血压患者60例作为研究对象，所有患者均符合WHO制定的高血压诊断标准，患者无精神疾病及认知障碍，患者本人均签署知情同意书。按随机数字表法将患者分为观察组与对照组，每组30例。观察组中男17例，女13例;年龄45～72岁，平均年龄(64.2±3.2)岁;病程2～13年，平均病程(7.2±1.4)年。对照组中男15例，女15例;年齡43～71岁，平均年龄(63.8±3.4)岁;病程3～14年，平均病程(7.4±1.2)年。比较2组患者的一般资料比较，差异无统计学意义(P>0.05)，具有可比性。, 百拇医药(吴朝俊)
关键词 美托洛尔;非洛地平;社区高血压;睡眠质量
Abstract Objective：To explore the clinical application value of two-drug combined with sleep intervention in community hypertension patients.Methods：Will be in January 2017 to May 2018 of 60 patients admitted in the community hypertension patients randomly divided into observation group(30 cases)and control group(30 cases)and control group，with felodipine treatment，observation group application of metoprolol combined felodipine duplex treatment drug treatment，and the sleep quality of patients with intervention and monitoring，observing two groups of patients before and after the clinical curative effect and treatment of sleep quality.Results：After 2 months of treatment，the systolic blood pressure and diastolic blood pressure in the observation group were lower than those before and after treatment.The incidence of adverse reactions during treatment was significantly lower in the observation group than in the control group.The quality of sleep in the observation group was better than that in the control group，and the difference was statistically significant(P<0.05).Conclusion：For hypertension in the community，combined application of metoprolol+felodipine therapy and synchronous implementation of sleep monitoring intervention can achieve good antihypertensive effect，improve patients′ sleep quality at the same time，and reduce adverse drug reactions，which is worthy of promotion.
Key Words Metoprolol;Felodipine;Community hypertension;Quality of sleep
中图分类号：R544.1;R338.63文献标识码：Adoi：10.3969/j.issn.2095-7130.2019.04.007
高血压是临床中常见的慢性疾病，此类患者大多分布在社区[1]。高血压患者的临床症状主要表现为血压处在正常水平以上，血压持续处在高水平状态可引起心脑血管疾病，这严重影响患者的生命质量及生命健康[2]。针对社区高血压，疾病的治疗上主要是通过合理用药将患者的血压稳定在正常水平，降低各种并发症的发生率，同时还需减少血压波动及反弹。高血压引起的应激反应等症状对患者心理状态影响明显，干扰正常睡眠，治疗高血压的同时，同步对合并睡眠障碍的患者进行睡眠干预可有效提高疗效，改善患者睡眠质量，提高血压控制率。本研究中，应用美托洛尔联合非洛地平治疗社区高血压并同时对患者进行睡眠干预，效果显著，详细报道如下。
1 资料与方法
1.1 一般资料 选取2017年1月至2018年5月昌平城区社区卫生服务中心收治的高血压患者60例作为研究对象，所有患者均符合WHO制定的高血压诊断标准，患者无精神疾病及认知障碍，患者本人均签署知情同意书。按随机数字表法将患者分为观察组与对照组，每组30例。观察组中男17例，女13例;年龄45～72岁，平均年龄(64.2±3.2)岁;病程2～13年，平均病程(7.2±1.4)年。对照组中男15例，女15例;年齡43～71岁，平均年龄(63.8±3.4)岁;病程3～14年，平均病程(7.4±1.2)年。比较2组患者的一般资料比较，差异无统计学意义(P>0.05)，具有可比性。, 百拇医药(吴朝俊)