氨基末端脑钠肽前体在高龄心力衰竭患者中截止点的选择(1)
【摘要】 目的：探讨氨基末端脑钠肽前体(N terminal probrain natriuretic peptide，NT-proBNP)检测在75岁以上心力衰竭患者(Heart Failur，HF)的临床意义，并分析其截止点的选择。方法：选择75岁以上的HF患者136例，年龄大于75岁的健康老年人136例为对照组，对照组和HF组(治疗前)均接受心脏彩超和NT-proBNP的检测，对比两组指标差异;分别计算采用NT-proBNP(2000pg/ml)、LVEF(45%)和Fs(21%)作为截止点的敏感度、特异度和诊断符合率，并进行对比分析。结果：HF组左心室射血分数(LVEF)平均值较对照组高(P<0.001)，左室内径缩短率(Fs)较对照组低(P<0.001)，NT-proBNP较对照组明显增高(P<0.001)，且NT-proBNP随着心功能的逐渐加重而逐渐升高，两者呈正相关;使用NT-proBNP>2000pg/ml作为诊断75岁以上AHF的指标敏感性特异度和诊断符合率较以LVEF≥45%或Fs<21%为诊断指标较高。结论：NT-proBNP诊断HF患者具有较高的便捷性和优越性，对于75岁以上的老年人，可选择2000pg/ml作为HF的截止点。
, 百拇医药
【关键词】 氨基末端脑钠肽前体;心力衰竭
【中图分类号】R541.6 【文献标识码】B 【文章编号】2095―8439(2015)04―0009―03
Selection of the cutoff point of the N-terminal pro brain natriuretic peptide in the elderly patients with heart failure
Yang Ling Yu Chunlian Tang Wanchun (Department of internal medicine， the Fourth Affiliated Hospital of Mongolia Medical University， Inner Mongolia， Baotou， 014030)
, 百拇医药
【Abstract】 Objective to investigate the amino terminal pro brain natriuretic peptide precursor (N terminal probrain natriuretic peptide， NT proBNP) detection in over 75 years of age or older HF) in patients with congestive heart failure (heart Failur clinical significance， and analysis the cut-off point for the choice. Methods 136 patients 75 years of age or older HF patients older than 75 years of healthy elderly people 136 cases as control group， control group and HF group (before treatment) underwent echocardiography and NT proBNP detection， differences between two groups of indices， were calculated using left ventricular ejection fraction (LVEF) and NT proBNP (2000pg/ml) (45%) and FS (21%) as a cutoff point of sensitivity， specificity， and diagnostic coincidence rate， and carries on the contrast analysis. Results HF group， the left ventricular ejection fraction (LVEF) mean value is higher than the control group (P < 0.001) ， left ventricular internal diameter shortening (FS) compared with the control group (P < 0.001) ， NT proBNP than the control group increased significantly (P < 0.001) and NT proBNP with cardiac function of gradually increasing， there was a positive correlation between; use NT proBNP > 2000pg/ml as diagnosis over the age of 75 AHF index sensitivity specificity and diagnostic coincidence rate compared with left ventricular ejection fraction (LVEF) is more than or equal to 45% or FS < 21% higher diagnostic index. Conclusion NT-proBNP has a high convenience and superiority in the diagnosis of HF， and can choose 2000pg/ml as the cutoff point of HF for the elderly over 75 years old., 百拇医药(杨玲 于春莲 汤万春)
, 百拇医药
【关键词】 氨基末端脑钠肽前体;心力衰竭
【中图分类号】R541.6 【文献标识码】B 【文章编号】2095―8439(2015)04―0009―03
Selection of the cutoff point of the N-terminal pro brain natriuretic peptide in the elderly patients with heart failure
Yang Ling Yu Chunlian Tang Wanchun (Department of internal medicine， the Fourth Affiliated Hospital of Mongolia Medical University， Inner Mongolia， Baotou， 014030)
, 百拇医药
【Abstract】 Objective to investigate the amino terminal pro brain natriuretic peptide precursor (N terminal probrain natriuretic peptide， NT proBNP) detection in over 75 years of age or older HF) in patients with congestive heart failure (heart Failur clinical significance， and analysis the cut-off point for the choice. Methods 136 patients 75 years of age or older HF patients older than 75 years of healthy elderly people 136 cases as control group， control group and HF group (before treatment) underwent echocardiography and NT proBNP detection， differences between two groups of indices， were calculated using left ventricular ejection fraction (LVEF) and NT proBNP (2000pg/ml) (45%) and FS (21%) as a cutoff point of sensitivity， specificity， and diagnostic coincidence rate， and carries on the contrast analysis. Results HF group， the left ventricular ejection fraction (LVEF) mean value is higher than the control group (P < 0.001) ， left ventricular internal diameter shortening (FS) compared with the control group (P < 0.001) ， NT proBNP than the control group increased significantly (P < 0.001) and NT proBNP with cardiac function of gradually increasing， there was a positive correlation between; use NT proBNP > 2000pg/ml as diagnosis over the age of 75 AHF index sensitivity specificity and diagnostic coincidence rate compared with left ventricular ejection fraction (LVEF) is more than or equal to 45% or FS < 21% higher diagnostic index. Conclusion NT-proBNP has a high convenience and superiority in the diagnosis of HF， and can choose 2000pg/ml as the cutoff point of HF for the elderly over 75 years old., 百拇医药(杨玲 于春莲 汤万春)