PredictorTM风险评估软件在子痫前期高危人群预测中的价值探析(1)
【摘 要】 目的：對PredictorTM风险评估软件采用的子痫前期预测模型进行外部确认，评估其临床使用价值。方法：选取本院收治的有子痫前期高危因素的孕妇，于孕11～15+6周测定平均动脉压(MAP)、血清妊娠相关蛋白A(PAPP-A)、胎盘生长因子(PLGF)，通过PredictorTM风险评估软件预测子痫前期高风险孕妇共109例，分为研究组A和研究组B，研究组A为51例，采用规范化口服阿司匹林干预;研究组B为58例，规范产检未进行阿司匹林干预。同时纳入同期检测的低风险孕妇115例作为对照组，比较三组高危因素、子痫前期发生率及相关妊娠结局指标。结果：研究组孕前高血压和年龄>35岁的发生率分别为5.5%和11.9%，显著高于对照组的0.0%和2.6%(P<0.05)。研究组A子痫前期发生率和早产率分别为7.8%和2.0%，均显著低于研究组B的22.4%和15.5%(P<0.05)。对照组子痫前期发生率、早产率、剖宫产率分别为0.9%、1.7%和30.4%，均显著低于研究组B的22.4%、15.5%和53.4%(P<0.05)。结论：PredictorTM风险评估软件应用于有子痫前期高危因素的孕妇，可有效地筛查出高风险孕妇，并行及早干预，可以有效降低子痫前期的发生和由此带来的不良妊娠结局。
, 百拇医药
【关键词】 子痫前期;高危因素;PredictorTM风险评估软件;阿司匹林
[Abstract] Objective：The pre-eclampsia predictive model for early pregnancy using PredictorTM risk assessment software was externally validated to assess its clinical value. Methods：Pregnant women with pre-eclampsia risk factors were enrolled in our hospital. Mean arterial pressure (MAP)， serum pregnancy-related protein A (PAPP-A)， placental growth factor (PLGF) were measured at 11～15+6 weeks of pregnancy， and PredictorTM was used. Risk assessment software predicted 109 pre-eclampsia high-risk pregnant women， divided into study group A and study group B， study group A was 51 cases， standardized oral aspirin intervention; study group B was 58 cases， standardized production test did not perform aspirin intervention . At the same time， 115 low-risk pregnant women were included in the control group during the same period， and the risk factors of pre-eclampsia and related pregnancy outcomes were compared among the three groups. Results：The incidence of pre-pregnancy hypertension and age >35 years in the study group was 5.5% and 11.9%， respectively， which were significantly higher than the control group at 0.0% and 2.6% (P<0.05). The incidence and premature rate of preeclampsia in study group A were 7.8% and 2.0%， respectively， which were significantly lower than 22.4% and 15.5% of study group B (P<0.05). The incidence of preeclampsia， premature rate， and cesarean section in the control group were 0.9%， 1.7%， and 30.4%， respectively， which were significantly lower than 22.4%， 15.5%， and 53.4% of study group B (P<0.05).Conclusion： PredictorTM risk assessment software is applied to pregnant women with high risk factors of pre-eclampsia. It can effectively screen high-risk pregnant women and intervene in early intervention， which can effectively reduce the incidence of pre-eclampsia and the resulting adverse pregnancy outcome.
[Key words]Preeclampsia;High risk factors;PredictorTM risk assessment software;Aspirin, http://www.100md.com(杜佳丽 戚亚兰)
, 百拇医药
【关键词】 子痫前期;高危因素;PredictorTM风险评估软件;阿司匹林
[Abstract] Objective：The pre-eclampsia predictive model for early pregnancy using PredictorTM risk assessment software was externally validated to assess its clinical value. Methods：Pregnant women with pre-eclampsia risk factors were enrolled in our hospital. Mean arterial pressure (MAP)， serum pregnancy-related protein A (PAPP-A)， placental growth factor (PLGF) were measured at 11～15+6 weeks of pregnancy， and PredictorTM was used. Risk assessment software predicted 109 pre-eclampsia high-risk pregnant women， divided into study group A and study group B， study group A was 51 cases， standardized oral aspirin intervention; study group B was 58 cases， standardized production test did not perform aspirin intervention . At the same time， 115 low-risk pregnant women were included in the control group during the same period， and the risk factors of pre-eclampsia and related pregnancy outcomes were compared among the three groups. Results：The incidence of pre-pregnancy hypertension and age >35 years in the study group was 5.5% and 11.9%， respectively， which were significantly higher than the control group at 0.0% and 2.6% (P<0.05). The incidence and premature rate of preeclampsia in study group A were 7.8% and 2.0%， respectively， which were significantly lower than 22.4% and 15.5% of study group B (P<0.05). The incidence of preeclampsia， premature rate， and cesarean section in the control group were 0.9%， 1.7%， and 30.4%， respectively， which were significantly lower than 22.4%， 15.5%， and 53.4% of study group B (P<0.05).Conclusion： PredictorTM risk assessment software is applied to pregnant women with high risk factors of pre-eclampsia. It can effectively screen high-risk pregnant women and intervene in early intervention， which can effectively reduce the incidence of pre-eclampsia and the resulting adverse pregnancy outcome.
[Key words]Preeclampsia;High risk factors;PredictorTM risk assessment software;Aspirin, http://www.100md.com(杜佳丽 戚亚兰)