陈 凯 傅麒宁 赵 渝

    (重庆医科大学附属第一医院血管外科，重庆 400016)

    临床论著?

    替罗非班治疗急性四肢远端动脉缺血安全性和有效性评价

    陈 凯 傅麒宁 赵 渝*

    (重庆医科大学附属第一医院血管外科，重庆 400016)

    目的：探讨替罗非班在急性四肢远端动脉缺血的应用效果。

    方法：总结和分析2012年01月至2015年04月重庆医科大学附属第一医院血管外科收治的使用替罗非班持续微量泵入治疗急性四肢远端动脉缺血患者的临床资料。

    结果：重庆医科大学附属第一医院收治的7例急性四肢远端动脉缺血患者均使用替罗非班进行非手术治疗，所有患者肢端缺血状况明显改善甚至完全缓解，降低了截指(趾)率，且未出现严重出血等相关并发症，出院后继续口服抗血小板药物治疗，随访结果良好。

    结论：替罗非班治疗无法手术的急性四肢远端动脉缺血疗效好，且安全性高。

    急性远端动脉缺血；替罗非班；安全性；有效性

    Objective:Evaluate the effcacy and safety of tirofban in acute distal limb artery ischemia.

    Methods:Analysis all the cases with acute distal limb artery ischemia accepting the therapy of continuous infusion of tirofban from 2012-01 to 2015-04 in our hospital.

    Results:All of the 7 cases received the treatment of tirofiban.All these 7 patients’ limb ischemic conditions improved signifcantly and some of them even completely remitted.The effcacy rate was 100%.Ⅰt decreased the rate of amputation obviously.There were no serious complications such as massive hemorrhage at the same time.All patients accepted further anti-platelet therapy when discharged and the follow-up showed that there was no recurrence. ......