【摘 要】颗粒蛋白前体(progranulin，PGRN)是一种内源性糖蛋白，广泛表达于多种组织细胞，如神经干细胞。它在神经细胞的生长分化，损伤后的炎性反应等过程中发挥重要的生理作用。尤其是在缺血性脑卒中调节炎症反应的发展过程，减轻机体受到的损害。

    【关键词】颗粒蛋白前体；缺血性脑卒中；炎症反应

    【Abstract】Progranulin (PGRN) is an endogenous glycoprotein that is widely expressed in a variety of tissue cells， such as neural stem cells. It plays an important physiological role in the process of growth and differentiation of nerve cells and inflammatory reactions after injury. Especially in the ischemic stroke， the development of the inflammatory response is regulated ......