杜 慧，赵 婧，嘎 琴，刘玉红，汤 锋，杨应忠，刘永年*

    (1.青海大学医学院基础医学部，青海 西宁810001;2.青海大学高原医学研究中心，青海西宁810001)

    1 INTRODUCTION

    High-altitude pulmonary edema(HAPE)is noncardiogenic pulmonary edema that usually occurs at altitudes above 2 500 m in rapidly ascending nonacclimatized individuals within the first week after arrival[1，2].It is generally known that HAPE tends to be associated with exaggerated pulmonary hypertension，with edema in pulmonary interstitial tissue and alveoli.It was defined as a noninflammatory hemorrhagic pulmonaryedema，which may evolve with time infeatures of secondary inflammation[3].Investigations showed circulating inflammatory markers are upregulated at high altitude[4].HAPE patients showed the immune cells，and inflammatory markers markedly elevated in the bronchoalveolar lavage fluid，and speculated that hypoxiainduced inflammation at high altitude may contribute to the development of HAPE[5].

    NR3C1(Nuclear Receptor Subfamily 3，Group C，Member 1)gene，which is located on chromosome 5q31-32，codes for the human glucocorticoid receptor(GR)，plays an important role in inflammation.Glucocorticoids(GCs)has various effects ......