花岡正幸

    (日本信州大学医学院第一医学部 ，呼吸性疾病、感染性疾病和过敏性疾病学部，日本 松本 390-8621)

    1 Introduction

    Highland is a low-oxygen environment，and alveolar hypoxia caused by reduced inhalation oxygen partial pressure induces various physiological changes in the body.When a human rapidly reaches high altitude，acclimation of the body including the cardiorespiratory system occurs to adapt with the environment，but dysadaptation occurs and acute mountain sickness develops in some individuals.High-altitude pulmonary edema(HAPE)is the severest form of acute mountain sickness，and it is prototype pulmonary edema induced in healthy individuals by hypoxia，low pressure，exercise load，and coldness.

    2 Clinical features of HAPE[1，2]

    HAPE is noncardiogenic pulmonary edema developing in healthy individuals within 48～96 hours after rapidly reaching high altitude.It is often complicated by high-altitude cerebral edema and progresses to a serious state，resulting in death when rescue is delayed.In Japan，most patients are climbers，and a few cases occur yearly.On the other hand ......