舰船燃烧后有毒烟雾对大鼠肺组织损伤的长期影响(1)
舰船燃烧后有毒烟雾对大鼠肺组织损伤的长期影响,烟雾吸入,肺损伤,CK19
【摘要】目的:明确舰船火灾中有毒烟雾吸入后是否对肺组织有长期的损伤,并探讨其机制。方法:大鼠肺组织病理学HE染色检查,气管粘膜原代细胞培养及CK19免疫荧光染色,激光共聚焦显微镜观察。结果:与对照组相比,烟雾吸入后3d可引发急性肺损伤,烟雾吸入后3m可引发慢性肺损伤,烟雾吸入后3m组细胞胞质中CK19表达的绿色荧光明显增强。结论:有毒烟雾吸入后可对大鼠肺组织造成长期慢性损伤,并有可能导致支气管粘膜上皮细胞向恶性转化。【关键词】烟雾吸入;肺损伤;CK19
Long term injury of lung tissue by smoke inhalation in rats after ship burning
Ying Xie, Xue Chen, You Hu, Ying Wang*
Huanghe North Avenue, Shenyang, Liaoning, Shenyang 110034, Liaoning, China
Abstract: Objective: This study was to determine whether long-term damage to lung tissue is caused by inhalation of toxic fumes in ship fires and to explore mechanisms. Methods: Histopathological examination of lung tissue in rats was performed by HE ......
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