[摘要]目的观察氟伏沙明联合团体认知行为治疗(GCBT)对强迫症病人的疗效。方法将按照精神障碍诊断统计手册第4版(DSM-Ⅳ)标准确诊的强迫症病人60例随机分为2组，实验组30例使用氟伏沙明联合GCBT治疗，对照组30例单纯使用氟伏沙明治疗。采用Yale-Brown强迫量表(Y-BOCS)、汉密尔顿焦虑量表(HAMA)、SF-36健康调查简表(SF-36)评定疗效。结果治疗12周后，实验组和对照组病人平均Y-BOCS、HAMA得分均较治疗前明显下降，但是两组间比较差异无统计学意义(P>0.05);实验组病人治疗后SF-36评分较治疗前显著升高(t=2.01，P<0.05)，实验组SF-36评分改善优于对照组(F=8.37，P<0.01)。结论氟伏沙明联合GCBT治疗和氟伏沙明单药治疗均能有效改善强迫症病人的强迫症状和焦虑情绪，但联合治疗能更有效地提高强迫症病人的生活质量。

    [关键词]强迫性障碍;团体认知行为治疗;氟伏沙明;治疗结果

    [中图分类号]R749.91[文献标志码]A[文章编号] 2096-5532(2018)06-0683-04

    CLINICAL EFFECT OF FLUVOXAMINE COMBINED WITH GROUP COGNITIVE-BEHAVIORAL THERAPY IN TREATMENT OF PATIENTS WITH OBSESSIVE-COMPULSIVE DISORDER "WANG Ke， XU Yali， XUE Junqiang， YUAN Jiao， ZENG Botao(Clinical Psychology， Qingdao Municipal Hospital， Qingdao 266011， China)

    [ABSTRACT]ObjectiveTo investigate the clinical effect of fluvoxamine combined with group cognitive-behavioral therapy (GCBT) in patients with obsessive-compulsive disorder (OCD). MethodsA total of 60 patients who were diagnosed with OCD according to Diagnostic and Statistical Manual of Mental Disorders (4th Edition) were enrolled and randomly divided into experimental group (treated with fluvoxamine combined with GCBT) and control group (treated with fluvoxamine alone) ......