[摘要]目的探讨基底外侧杏仁核(BLA)微量注射Kv7钾离子通道激动剂或拮抗剂对大鼠条件性味觉厌恶(CTA)情绪记忆获取及提取的影响。方法成年雄性Wistar大鼠BLA埋管后随机分为8组，实验组分别于不同时间经BLA微量注射Kv7钾离子通道激动剂(retigabine)或拮抗剂(XE-991)，其对照组注射生理盐水。采用CTA行为范式评价Kv7通道激动剂及拮抗剂对CTA情绪记忆获取及提取的影响。结果训练前注射retigabine组大鼠味觉厌恶指数较注射生理盐水组大鼠明显下降，差异有统计学意义(t=3.384，P<0.05)；记忆提取前注射retigabine组大鼠味觉厌恶指数与注射生理盐水组大鼠比较差异无显著性(P>0.05)。训练前和记忆提取前注射XE-991组大鼠与注射生理盐水组大鼠相比，味觉厌恶指数差异均无显著性(P>0.05)。结论Kv7钾离子通道的激活抑制CTA记忆获取，该作用可能与降低BLA神经元兴奋性有关。

    [关键词]钾通道，电压门控；基底外侧核；情绪；记忆；大鼠

    [中图分类号]R338.2[文献标志码]A[文章编号]2096-5532(2023)03-0364-03

    doi：10.11712/jms.2096-5532.2023.59.019[开放科学(资源服务)标识码(OSID)]

    [网络出版]https：//kns.cnki.net/kcms/detail/37.1517.R.20230303.1117.005.html;2023-03-0610：09：43

    EFFECT OF KV7 CHANNEL ON CONDITIONED TASTE AVERSION MEMORY IN RATS GAO Shanshan， YANG Xin， FU Jiahao， SHAO Fei， ZHAI Hongxia， ZHOU Yu" (Department of Physiology and Pathophysiology， School of Basic Medicine， Qingdao University， Qingdao 266071， China)

    [ABSTRACT]ObjectiveTo investigate the effect of microinjection of Kv7 channel agonist or antagonist into the basolateral amygdala (BLA) on the acquisition and retrieval of conditioned taste aversion (CTA) memory in rats. MethodsAdult male Wistar rats were randomly divided into eight groups after BLA catheter embedding. The rats in experimental groups were given intra-BLA microinjection of Kv7 channel agonist (retigabine) or antagonist (XE-991) ......