[摘要]目的探讨原发性血小板增多症继发骨髓纤维化(PET-MF)的临床特点及诊治方法。方法报告1例PET-MF病人，结合相关的文献复习，总结其临床特点及诊治经验。结果病人有原发性血小板增多症病史9年，期间给予羟基脲、干扰素、阿司匹林治疗，疾病进展至骨髓纤维化后，给予芦可替尼治疗一度有效，后病人血小板计数持续增高，出现剧烈骨痛，在原来方案基础上联合塞利尼索治疗，病人骨痛感消失、脾脏缩小，治疗效果明显。结论PET-MF病人疾病进展后会出现骨痛、发热，使用包括JAK2抑制剂芦可替尼在内的传统治疗方案效果不佳时，可考虑联合新药核输出蛋白1抑制剂塞利尼索控制疾病进展及缓解病人症状。

    [关键词]血小板增多，原发性；骨髓纤维化；塞利尼索；核输出蛋白1抑制剂；治疗学；病例报告

    [中图分类号]R558.3;R551.3[文献标志码]B[文章编号]2096-5532(2023)03-0442-04

    doi：10.11712/jms.2096-5532.2023.59.089[开放科学(资源服务)标识码(OSID)]

    [网络出版]https：//kns.cnki.net/kcms2/detail/37.1517.R.20230801.1100.001.html;2023-08-0114：51：29

    SELINEXOR FOR THE TREATMENT OF POST-ESSENTIAL THROMBOCYTHEMIA MYELOFIBROSIS： A CASE REPORT AND LITERATURE REVIEW ZHOU Chunxiao， WU Zhimin， WU Chunyan， ZHAO Xindong， GU Huali， WU Shaoling (Medical College of Qingdao University， Qingdao 266071， China)

    [ABSTRACT]ObjectiveTo investigate the clinical features， diagnosis， and treatment of post-essential thrombocythemia myelofibrosis (PET-MF). MethodsThis article reports a case of PET-MF and summarizes its clinical features and the expe-rience in diagnosis and treatment with reference to related articles. ResultsThe patient had a history of essential thrombocythemia for 9 years and were treated with hydroxyurea ......