[摘要]儿童接触丙泊酚可能对神经元造成毒性损伤，并且与其成年后长期认知功能下降有关。其原因可能是由于多种机制诱导的神经细胞凋亡和抑制神经所致，其中microRNAs在这一过程中起着关键作用。本文对microRNAs在丙泊酚诱导的神经毒性作用中的作用和影响进行综述，为精准的脑神经保护提供参考依据。

    [关键词]二异丙酚；中枢神经系统药物；神经中毒综合征；微RNAs；综述

    [中图分类号]R595.471;R977.9[文献标志码]A[文章编号]2096-5532(2023)03-0466-05

    doi：10.11712/jms.2096-5532.2023.59.103[开放科学(资源服务)标识码(OSID)]

    [网络出版]https：//link.cnki.net/urlid/37.1517.R.20230807.1616.007;2023-08-0809：10：48

    RESEARCH PROGRESS ON ROLE OF MICRORNAS IN PROPOFOL-INDUCED NEUROTOXICITY" ZHUANG Zhao， CAO Hong， DIAO Yujing， WANG Shoushi(Department of Anesthesiology， Qingdao Central Hospital Affiliated to Qingdao University， Qingdao 266042， China)

    [ABSTRACT]Exposure to propofol in children may cause damage to neurons and even a long-term cognitive decline in adulthood. This may involve multiple mechanisms that induce neuronal apoptosis and neural inhibition， in which microRNAs play a key role. This paper reviews the role of microRNAs in propofol-induced neurotoxicity， aiming to provide a basis for precise cerebral neuroprotection.

    [KEY WORDS]propofol; central nervous system agents; neurotoxicity syndromes; microRNAs; review ......