[摘要]

    多囊卵巢综合征(PCOS)是一种以稀发排卵或无排卵、高雄激素血症及卵巢多囊样改变为主要特征的代谢性疾病。目前尚无动物模型能够全面地覆盖PCOS所有临床表现。本文综述了常见的PCOS动物模型，并总结了其生殖与代谢特征。

    [关键词] 多囊卵巢综合征；疾病模型，动物；综述

    [中图分类号] R711.75

    [文献标志码] A

    [文章编号] 2096-5532(2024)05-0787-04

    doi：10.11712/jms.2096-5532.2024.60.171

    [网络出版] https：//link.cnki.net/urlid/37.1517.R.20241127.0854.001;2024-11-27 15：01：25

    Research advancesin animal models of polycystic ovary syndrome

    LIU Fang， XU Lin

    (Department of Obstetrics and Gynecology， The Affiliated Hospital of Qingdao University， Qingdao 266003， China)

    [Abstract] Polycystic ovary syndrome (PCOS) is a metabolic disease characterized by oligo-ovulation or anovulation， hyperandrogenism， and polycystic ovary changes. At present， no animal model can fully cover all clinical manifestations of PCOS. This article reviews the common animal models of PCOS and summarizes its reproductive and metabolic characteristics.

    [Key words] polycystic ovary syndrome; disease models， animal; review

    多囊卵巢综合征(PCOS)是导致育龄期女性排卵障碍不孕的主要原因之一，其患病率大约为20%[1-2]。PCOS是一种高度异质性疾病，其临床表现以生殖异常和代谢异常为主[3-4] ......