[关键词] 动脉粥样硬化；血管钙化；碳酸酐酶II；乙酰唑胺；小鼠，近交C57BL[中图分类号] R361.1；R977.3 [文献标志码]A [文章编号] 2096-5532(2025)03-0376-05doi：10.11712/jms.2096-5532.2025.61.093 [开放科学(资源服务)标识码(OSID)][网络出版] https：//link.cnki.net/urlid/37.1517.R.20250724.1505.003；

    2025-07-24 17：42：05

    Effects of acetazolamide on atherosclerotic plaque formation and calcification in miceLIU Han ，AN Yi (Department of Cardiology，The Affiliated Hospital of Qingdao University，Qingdao 266oo3，China)

    [Abstract]ObjectiveToinvestigate the efects of acetazolamideonatherosclerotic plaque formationand vascularcalcification in mice. MethodsFour-week-old Apoe^-/-(n=3) and wild-type ( n=3 ) C57BL/6 mice were fed for 21 weeks，and subsequently，body weight and serum lipid levels were compared. Twelve l2-week-old Apoe^-/- mice were divided into control group ( n=8 ，given normal saline) and experimental group ( ，given acetazolamide at 40mg/kg .After 2 weeks of treatment，aortic tissues wereharvestedtoevaluate plaquearea withHEstaining ......