[关键词] 糖尿病；天花粉；网络药理学；分子对接；过氧化物酶体增殖物激活受体[中图分类号] R587.1;R285.5 [文献标志码]A [文章编号] 2096-5532(2025)03-0381-06doi：10.11712/jms.2096-5532.2025.61.104 [开放科学(资源服务)标识码(OSID)][网络出版]https：//link.cnki.net/urlid/37.1517.R.20250731.1031.003; 2025-07-3113：05：36

    Mechanism of actionofRadixTrichosanthis intreatment of diabetesmelitus：Astudybasedonnetwork pharmacologyand molecular docking ZHANG Lei， CAO Yang，WANG Xiaoping ， HE KanLiang， YUAN Qiuzhen，LI Ting(Department of Pharmacy， Shanxi Provincial Hospital of Chinese Medicine，Xi'an 7looo3，China)

    [Abstract]ObjectiveToinvestigatethemechanismofactionofRadixTrichosanthisinthetreatmentof diabetesmellitus based on network pharmacologyand moleculardocking.MethodsTCMSPdatabase was used toobtain theffectiveconstituents of Radix Trichosanthis，nd SwissTargetPredictiondataplatform wasusedtoobtainthecoresponding targets.MalaCardsdatabase wasusedtoobtainthetargetsasociatedwithdiabetesmelltus.Thecommontargetsofthedrugandthediseasewereobtained，and then STRING database and Cytoscape software wereused toconstruct a protein-proteininteraction(PPI)network andidentifythe coretargets.Matescape database was usedto perform the gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes (KEGG)analyses.Autodock Vina wasusedtoperformmoleculardockingbetweenthecoretargetsandthecorespondingeffective constituents.ResultsAtotalof28targets wereobtainedforRadixTrichosanthisinthetreatmentofdiabetesmelitus ......