[关键词] 帕金森病；多功能纳米颗粒；羟多巴胺；运动活动；小鼠[中图分类号]R338.2；R742.5 [文献标志码]A [文章编号] 2096-5532(2025)03-0341-04doi：10.11712/jms.2096-5532.2025.61.085 [开放科学(资源服务)标识码(OSID)][网络出版]https：//link.cnki.net/urlid/37.1517.R.20250716.1047.008; 2025-07-1615：09：52

    Effectof polydopaminenanoparticlesonthemotorbehaviorof micewithParkinson’sdiseaseinducedby6-hydroxydopamine ZHANG Jing，SHI Yaying，ZHAO Di，XIE Junxia，SHI Limin (DepartmentofPhysiologyand Pathophysiology，School ofBasic Medicine，Qingdao University，Qingdao 266071，China)

    [Abstract]ObjectiveToinvestigate theeffectof polydopamine nanoparticles(PDANPs)onthe motor behaviorof mice with Parkinson’s disease(PD)inducedby6-hydroxydopamine(6-OHDA).MethodsMaleC57BL/6 mice，aged8 weks，were selectedas experimentalanimalsand weredivided intoControl group，PDANPstreatmentgroup(PDA group)，modelgroup(6- OHDA group)，and combined treatment group(6-OHDA + PDA group). The stereotactic injection technique was used to inject 2 μL of working solution intothecorpus striatum.Aftertwo weeks ......