[关键词]帕金森病;1-甲基-4-苯基-1，2，3，6-四氢吡啶;光甘草定;纳米颗粒给药系统;运动活动;小鼠[中图分类号] R338.2；R742.5 [文献标志码]A [文章编号] 2096-5532(2025)03-0317-05doi：10.11712/jms.2096-5532.2025.61.075 [开放科学(资源服务)标识码(OSID)][网络出版]https：//link.cnki.net/urlid/37.1517.R.20250709.1559.002; 2025-07-10 11：57：52

    [Abstract]ObjectiveTo prepare glabridin nanoparticle，andto investigateits efectonmotorfunctionin mice with Parkinson'sdisease(PD)induced by1-methyl-4-phenyl-1，2，3，6-tetrahydropyridine(MPTP).MethodsGlabridinand polydopamine(PDA)wereused tosynthesize glabridin nanoparticles(Glab-PDANPs)through self-assmbly，andthen Glab-PDA NPs werecharacterized.A total of 24 C57BL/6 mice，aged 8 wees，were randomlydivided into MPTPgroup，Glab-PDA NPs treatment group，and control group，with 8 miceineach group.The micein the MPTP group and the Glab-PDA NPstreatment group were given intraperitoneal njectionof MPTPtoestablishamodelofsubacutePD.The miceinthe Glab-PDANPs treatment group were given injectionofGlab-PDANPsthroughthecaudalveinsinceday3before modelingtilltheendof modeling ......