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超声对PC12细胞的调控及对6-OHDA诱导的帕金森病小鼠模型运动行为的影响
http://www.100md.com 2025年9月2日 青岛大学学报(医学版) 2025年第3期
     [关键词」 帕金森病;超声波;PC12细胞;黑质;小鼠;运动活动[中图分类号]R338.2 [文献标志码]A [文章编号] 2096-5532(2025)03-0322-05doi:10.11712/jms.2096-5532.2025.61.076 [开放科学(资源服务)标识码(OSID)][网络出版]https://link.cnki.net/urlid/37.1517.R.20250709.1559.003; 2025-07-10 14:18:01

    Regulatory effects of ultrasoud onPC12cels and motorbhaviors of mouse modelof 6-OHDA-induced Parkinson’sdiseaseZHONG Guangjun,JIA Guorui,ZHAODi,XIEJunxia(Department of Physiologyand Pathophysiology,School of Basic Medicine, Qingdao Medical College of Qingdao University,Qingdao 266o71,China)

    [Abstract]ObjectiveTo investigate the effects of ultrasound(US)on pheochromocytoma (PC12)celsand the motor behaviorsofamousemodelof6-hydroxydopamine(6-OHDA)inducedParkinson'sdisease.MethodsPC12celsweredividedinto control group and US group (stimulated with US),and the Ca2+ fluorescence intensity of the cells in the two groups was measured. C57BL/6J mice were divided into control group,model group,and US group to receive injection of normal saline,6-OHDA solution,and6-OHDA solutionintothestriatum,respectively;after2weeks,gaitanalysis wasperformedforthethre groups;and then ......

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