[关键词」转移性结直肠癌;人表皮生长因子受体 2;高通量核苷酸序列分析;循环肿瘤 DNA;分子靶向治疗[中图分类号]R735.3 [文献标志码]A [文章编号] 2096-5532(2025)03-0465-05doi：10.11712/jms.2096-5532.2025.61.072 [开放科学(资源服务)标识码(OSID)][网络出版]https：//link.cnki.net/urlid/37.1517.R.20250627.1107.004； 2025-06-2716：38：44

    Research advances inHER2 in advanced metastaticcolorectal cancerZHAO Peipei，WANG Zhihai，LI Mingyue，SUN Shuolan，JUFang(Schoolof Clinical Medicine，Shandong Second Medical University，Weifang 261ooo，China)

    [Abstract] Colorectal cancer is a common malignant tumor of the digestive tract，and about 20% of patients have distant me tastases at initial diagnosis，while 5% of metastatic colorectal cancer (mCRC) cases are of the human epidermal growth factor receptor2(HER2)varianttype.HER2-positive mCRC patients who have failed standard treatmentcansignificantly benefit from HER2-targetedtherapy.Thisarticlereviewstherecentresearchadvancesindetectionmethods ......