, ,

    (1.Department of Physiology,Zunyi Medical University,Zunyi Guizhou 563099，China；2.Department of Psychiatry and Behavioral Sciences,Northwestern University ,Chicago 60611，USA)

    Impact of corticotropin-releasing factor receptor 1 on alzheimer’s disease

    YanYan1,2,ChenYuanshou1,DongHongxin1,2

    (1.Department of Physiology,Zunyi Medical University,Zunyi Guizhou 563099，China；2.Department of Psychiatry and Behavioral Sciences,Northwestern University ,Chicago 60611，USA)

    Growing evidence suggests that stress-induced release of corticotrophin-releasing factor (CRF) and subsequent effects through CRF receptor 1(CRFR1),have been linked to Alzheimer's disease (AD) onset and progression.The main function of CRFR1 is to act as a key regulator of stress-induced changes of the hypothalamic-pituitary-adrenal (HPA) axis.However,given the fact that CRFR1 is widely located in brain areas that are associated with emotion and cognition,additional functions of CRF/CRFR1 signaling have been proposed,including the regulation of AD neuropathology.In particular,specific downstream signaling of CRFR1 can promote amyloid β-protein accumulation and tau phosphorylation,which can be blocked by CRFR1 antagonist.Thus,CRFR1 antagonists may have therapeutic potential for the prevention and treatment of AD.So we reviewed current literature and our studies to clarify the relationship between CRF/CRFR1 signaling and AD. ......